Jordan R Kuiper, Shelley H Liu, Bruce P Lanphear, Antonia M Calafat, Kim M Cecil, Yingying Xu, Kimberly Yolton, Heidi J Kalkwarf, Aimin Chen, Joseph M Braun, Jessie P Buckley
Few methods have been used to characterize repeatedly measured biomarkers of chemical mixtures. We applied latent profile analysis (LPA) to serum concentrations of four perfluoroalkyl and polyfluoroalkyl substances (PFAS) at four timepoints from gestation to age 12 years. We evaluated the relations between profiles and z-scores of height, body mass index, fat mass index, and lean body mass index at age 12 years (n = 218). We compared LPA findings with an alternative approach for cumulative PFAS mixtures using g-computation to estimate the effect of simultaneously increasing the area under the curve (AUC) for all PFAS...
February 23, 2024: American Journal of Epidemiology