Isidro Machado, Celia Requena, Raquel López-Reig, Antonio Fernández-Serra, Francisco Giner, Julia Cruz, Victor Traves, Javier Lavernia, Reyes Claramunt, Beatriz Llombart, José Antonio López-Guerrero, Antonio Llombart-Bosch
OBJECTIVES: We explored features of the angiosarcoma (AS) tumor microenvironment to discover subtypes that may respond to immunotherapy. METHODS: Thirty-two ASs were included. Tumors were studied by histology, immunohistochemistry (IHC), and gene expression profile using the HTG EdgeSeq Precision Immuno-Oncology Assay. RESULTS: Comparing cutaneous and noncutaneous ASs, the second group showed 155 deregulated genes, and unsupervised hierarchical clustering (UHC) delineated two groups: the first mostly cutaneous AS and the second mainly noncutaneous AS...
March 9, 2023: American Journal of Clinical Pathology