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American Journal of Clinical Pathology

https://read.qxmd.com/read/38643353/p53-immunohistochemistry-as-an-ancillary-tool-for-rapid-assessment-of-residual-disease-in-tp53-mutated-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#1
JOURNAL ARTICLE
Nivaz Brar, Lauren Lawrence, Eula Fung, James L Zehnder, Peter L Greenberg, Gabriel N Mannis, Tian Y Zhang, Dita Gratzinger, Jean Oak, Oscar Silva, Jason Kurzer, Brent Tan, Joshua R Menke, Sebastian Fernandez-Pol
OBJECTIVES: Measurable residual disease flow cytometry (MRD-FC) and molecular studies are the most sensitive methods for detecting residual malignant populations after therapy for TP53-mutated acute myeloid leukemia and myelodysplastic neoplasms (TP53+ AML/MDS). However, their sensitivity is limited in suboptimal aspirates or when the immunophenotype of the neoplastic blasts overlaps with erythroids or normal maturing myeloid cells. In this study, we set out to determine if p53 immunohistochemistry (IHC) correlates with MRD-FC and next-generation sequencing (NGS) in the posttherapy setting and to determine the utility of p53 IHC to detect residual disease in the setting of negative or equivocal MRD-FC...
April 20, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38642081/keratin-17-is-a-prognostic-and-predictive-biomarker-in-pancreatic-ductal-adenocarcinoma
#2
JOURNAL ARTICLE
Lyanne A Delgado-Coka, Lucia Roa-Peña, Sruthi Babu, Michael Horowitz, Emanuel F Petricoin, Lynn M Matrisian, Edik M Blais, Natalia Marchenko, Felicia D Allard, Ali Akalin, Wei Jiang, Brent K Larson, Andrew E Hendifar, Vincent J Picozzi, Minsig Choi, Kenneth R Shroyer, Luisa F Escobar-Hoyos
OBJECTIVES: To determine the role of keratin 17 (K17) as a predictive biomarker for response to chemotherapy by defining thresholds of K17 expression based on immunohistochemical tests that could be used to optimize therapeutic intervention for patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: We profiled K17 expression, a hallmark of the basal molecular subtype of PDAC, by immunohistochemistry in 2 cohorts of formalin-fixed, paraffin-embedded PDACs (n = 305)...
April 20, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38642073/early-identification-of-patients-at-risk-for-iron-deficiency-anemia-using-deep-learning-techniques
#3
JOURNAL ARTICLE
Nelly Estefanie Garduno-Rapp, Yee Seng Ng, Jenny L Weon, Sameh N Saleh, Christoph U Lehmann, Chenlu Tian, Andrew Quinn
OBJECTIVES: Iron-deficiency anemia (IDA) is a common health problem worldwide, and up to 10% of adult patients with incidental IDA may have gastrointestinal cancer. A diagnosis of IDA can be established through a combination of laboratory tests, but it is often underrecognized until a patient becomes symptomatic. Based on advances in machine learning, we hypothesized that we could reduce the time to diagnosis by developing an IDA prediction model. Our goal was to develop 3 neural networks by using retrospective longitudinal outpatient laboratory data to predict the risk of IDA 3 to 6 months before traditional diagnosis...
April 20, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38639326/concentration-of-voxelotor-in-sickle-cell-disease-can-be-estimated-using-electrophoresis-and-high-performance-liquid-chromatography
#4
JOURNAL ARTICLE
Susanna A Curtis, Elana Friedman, Caterina Minniti, Annie Nguyen Dang, Mira Pochron, Merin Thomas, Jaime Betancourt, Leena Vattappally, Andrew Crouch, Julissa Morales, Sean T Campbell
OBJECTIVES: Voxelotor can increase hemoglobin levels in patients living with sickle cell disease (SCD). A clinician who is monitoring voxelotor response may want to know whole-blood voxelotor concentration, but this cannot be measured in most clinical settings. However, voxelotor has been demonstrated to cause "peak splitting" in common methods of hemoglobin measurement such as capillary zone electrophoresis (CZE) and high-performance liquid chromatography (HPLC). We hypothesized that we could use the size of the peak split to estimate the whole-blood concentration...
April 18, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38637286/warm-reactive-autoantibodies-detected-by-solid-phase-technology-patient-characteristics-laboratory-features-and-clinical-significance
#5
JOURNAL ARTICLE
Douglas P Blackall, Jennifer T Little
OBJECTIVES: This study focused on the serology, clinical characteristics, and hemolytic potential of warm reactive autoantibodies detected by solid phase red cell adherence. METHODS: Ninety-seven patients with warm autoantibodies were evaluated. Serologic characteristics included the strength of solid phase reactivity, the results of tube-based ancillary testing, direct antiglobulin test and eluate results, and an assessment for contemporaneous alloantibodies. Clinical characteristics of the patients included age, sex, and primary diagnosis...
April 18, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38635300/auditing-plasma-transfusion-in-intensive-care-use-of-decision-time-interval-analysis
#6
JOURNAL ARTICLE
Walter H Dzik, Kristen Ruby, Patricia A R Brunker, Julia Collins, Hyun-Il Paik, Robert Makar
OBJECTIVES: To present a new method for displaying blood utilization data based on analysis of decision time intervals (DTIs). METHODS: Retrospective study of patients treated in a medical intensive care unit (ICU), surgical ICU, or postcardiac surgery ICU at an academic hospital between January 2018 and June 2023. Each patient's episode of care was divided into a series of DTIs. Transfusions during each time interval were recorded. RESULTS: In total, 16,562 patients received 6980 units of plasma and 21,034 units of red blood cells during 111,557 time intervals of care...
April 18, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38619043/comparative-analysis-of-chatgpt-and-bard-in-answering-pathology-examination-questions-requiring-image-interpretation
#7
JOURNAL ARTICLE
Sompon Apornvirat, Chutimon Namboonlue, Thiyaphat Laohawetwanit
OBJECTIVES: To evaluate the accuracy of ChatGPT and Bard in answering pathology examination questions requiring image interpretation. METHODS: The study evaluated ChatGPT-4 and Bard's performance using 86 multiple-choice questions, with 17 (19.8%) focusing on general pathology and 69 (80.2%) on systemic pathology. Of these, 62 (72.1%) included microscopic images, and 57 (66.3%) were first-order questions focusing on diagnosing the disease. The authors presented these artificial intelligence (AI) tools with questions, both with and without clinical contexts, and assessed their answers against a reference standard set by pathologists...
April 15, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38607807/comparison-of-the-solid-phase-red-cell-adherence-assay-and-tube-method-for-detection-and-identification-of-red-blood-cell-antibodies
#8
JOURNAL ARTICLE
Mohamed Abdelmonem, Alex Dussaq, Kathy Papakonstantino, Muharrem Yunce, Mrigender Singh Virk
OBJECTIVES: Identifying antibodies to red blood cell antigens is one of transfusion medicine's critical responsibilities. The International Society of Blood Transfusion recognizes 354 red blood cell antigens. Accurate identification of clinically significant alloantibodies is imperative for preventing hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. We compared the performance of the tube (polyethylene glycol-indirect antiglobulin test [PEG-IAT]) and solid-phase red cell adherence assay techniques...
April 12, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38597584/predictors-of-clinical-outcome-in-myeloproliferative-neoplasm-unclassifiable-a-bone-marrow-pathology-group-study
#9
JOURNAL ARTICLE
Genevieve M Crane, Julia T Geyer, Beenu Thakral, Sa A Wang, Geoffrey D Wool, Ke David Li, Adam R Davis, Leonardo Boiocchi, David Bosler, Carlos E Bueso-Ramos, Daniel A Arber, Tracy I George, Adam Bagg, Robert P Hasserjian, Attilio Orazi, Eric D Hsi, Heesun J Rogers
OBJECTIVES: Myeloproliferative neoplasm, unclassifiable (MPN-U, revised to MPN, not otherwise specified in the fifth edition of the World Health Organization classification) is a heterogeneous category of primary marrow disorders with clinical, morphologic, and/or molecular features that preclude classification as a more specific MPN subtype due to stage at diagnosis, overlapping features between MPN subtypes, or the presence of coexisting disorders. Compared with other MPN subtypes, the contribution of the mutational landscape in MPN-U in conjunction with other clinical and morphologic biomarkers to prognosis has been less well investigated...
April 10, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38591770/improving-resource-utilization-axillary-lymph-node-core-biopsy-triaging-for-lymphoma
#10
JOURNAL ARTICLE
Carl Dernell, John Astle, Abraham Bogachkov, Shelly Reimer, Anubha Wadhwa, Shadie S Majidi, Bethany Canales, Julie M Jorns
OBJECTIVES: To evaluate the utilization of hematopathology resources within our enterprise on axillary lymph node core biopsy (AxLNCB) specimens, particularly those obtained in the context of breast cancer screening. METHODS: The utilization of hematopathology resources was determined for all AxLNCB specimens over a 30-month period from across our enterprise, and chart review was performed for select patient demographics and radiographic features. The AxLNCB cases with benign histology were reviewed for subtyping of histologic patterns...
April 9, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38581145/side-scatter-ratio-of-the-cd105-positive-and-cd105-negative-red-blood-cell-fractions-is-useful-for-the-detection-of-low-grade-myelodysplastic-neoplasms-by-flow-cytometry
#11
JOURNAL ARTICLE
Zijan Wang, Pedro C Ciarlini, Kwadwo A Oduro, Ramya Gadde, Stacey O'Neill, Chen Zhao, Howard J Meyerson
OBJECTIVES: We assessed the utility of red blood cell (RBC) CD105 and side scatter (SSC) parameters by flow cytometry for the detection of low-grade myelodysplastic neoplasms (MDS) in bone marrow specimens. METHODS: Ten RBC parameters incorporating CD105 or SSC combined with the Meyerson-Alayed scoring system (MASS) metrics were retrospectively evaluated by flow cytometry for utility in detecting low-grade MDS (n = 56) compared with cytopenic controls (n = 86)...
April 6, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38567909/performance-of-gpt-4-vision-on-kidney-pathology-exam-questions
#12
JOURNAL ARTICLE
Jing Miao, Charat Thongprayoon, Wisit Cheungpasitporn, Lynn D Cornell
OBJECTIVES: ChatGPT (OpenAI, San Francisco, CA) has shown impressive results across various medical examinations, but its performance in kidney pathology is not yet established. This study evaluated proficiencies of GPT-4 Vision (GPT-4V), an updated version of the platform with the ability to analyze images, on kidney pathology questions and compared its responses with those of nephrology trainees. METHODS: Thirty-nine questions (19 text-based questions and 20 with various kidney biopsy images) designed specifically for the training of nephrology fellows were employed...
April 3, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38547227/low-board-pass-rates-in-blood-banking-transfusion-medicine
#13
JOURNAL ARTICLE
Gary W Procop, Tyler Sandersfeld, Mark K Fung
No abstract text is available yet for this article.
March 28, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38538079/mammary-pilar-metaplasia
#14
JOURNAL ARTICLE
Carla Stephan, Sandra Demaria, Syed A Hoda
No abstract text is available yet for this article.
March 27, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38527169/interobserver-reproducibility-of-cervical-histology-interpretation-with-and-without-p16-immunohistochemistry
#15
JOURNAL ARTICLE
Amy S Tao, Rosemary Zuna, Teresa M Darragh, Niels Grabe, Bernd Lahrmann, Megan A Clarke, Nicolas Wentzensen
OBJECTIVES: Histopathological diagnosis of colposcopically identified cervical lesions is a critical step for the recognition of cervical cancer precursors requiring treatment. Although there have been efforts to standardize the histologic diagnosis of cervical biopsy specimens, in terms of terminology and use of biomarkers, there is no uniform approach in the pathology community. Adjunctive p16 immunohistochemistry (IHC) can highlight precancer diagnoses, with use recommendations outlined by the Lower Anogenital Squamous Terminology project...
March 25, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38527168/four-distinct-ipsilateral-vestibular-schwannomas-a-case-of-mosaic-nf2-related-schwannomatosis
#16
JOURNAL ARTICLE
Alexandra E Tunkel, Emily R Youner, Hayk Barseghyan, Yulong Fu, Surajit Bhattacharya, Miriam Bornhorst, Ashkan S Monfared
OBJECTIVES: Distinguishing between sporadic and germline/mosaic NF2-related schwannomatosis is important to ensure that patients have appropriate long-term care. With this report, we describe a unique case of a patient with 4 ipsilateral schwannomas and identify a combination of sequencing modalities that can accurately diagnose mosaic NF2-related schwannomatosis. METHODS: We present a 32-year-old woman with a familial history of vestibular schwannoma in her father and right-sided schwannomas involving the apical and basal turns of cochlea, lateral semicircular canal, and internal auditory canal (IAC)...
March 25, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38513285/clinicopathologic-correlation-of-dermatologic-diseases-in-patients-with-darker-pigmentation
#17
JOURNAL ARTICLE
Sanjna Tripathy, Elizabeth Warbasse, Shira Ronen, Rami Al-Rohil, George F Cohen, Wei-Shen Chen, Anisha B Patel
OBJECTIVES: Cutaneous diseases that disproportionately affect patients with darker pigmentation and their histologic features are historically understudied and undertreated. This review article aims to highlight the key clinical features, histopathology, and diagnostic pearls of several cutaneous diseases that commonly present in patients with darker pigmentation. METHODS: A literature search was conducted, and a list of cutaneous diseases that frequently affect patients with darker pigmentation was compiled...
March 21, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38513276/laboratory-characterization-of-the-pediatric-b-t-subtype-of-mixed-phenotype-acute-leukemia-report-of-a-case-series
#18
JOURNAL ARTICLE
Irina Demina, Ekaterina Mikhailova, Elena Zerkalenkova, Alexandra Semchenkova, Julia Roumiantseva, Alexandra Borkovskaya, Evgeny Matveev, Dmitry Abramov, Dmitry Konovalov, Natalia Miakova, Natalia Ponomareva, Julia Belkina, Konstantin Kondratchik, Yulia Olshanskaya, Galina Novichkova, Alexander Karachunskiy, Alexander Popov
OBJECTIVES: Mixed-phenotype acute leukemia (MPAL) is a rare disease associated with difficulties in the correct lineage assignment of leukemic cells. One of the least common subtypes within this category is characterized by the simultaneous presence of B- and T-lineage-defining antigens. Each case of suspected B/T MPAL should be considered in light of all available laboratory and clinical data to avoid misdiagnosis. METHODS: In this study, we describe 6 pediatric patients who presented with leukemic blasts bearing B- and T-lineage antigens at diagnosis, including their clinical, immunophenotypic, morphologic, and cytogenetic characteristics...
March 21, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38513273/morules-and-%C3%AE-catenin-predict-pole-mutation-status-in-endometrial-cancer-a-pathway-to-more-cost-effective-diagnostic-procedures
#19
JOURNAL ARTICLE
Rujia Fan, Wanrun Lin, Ruijiao Zhao, Li Li, Rui Xin, Yunfeng Zhang, Yuxin Liu, Ying Ma, Yiying Wang, Yue Wang, Wenxin Zheng
OBJECTIVES: The characterization of DNA polymerase epsilon (POLE) mutations has transformed the classification of endometrial endometrioid carcinomas (EECs), highlighting the need for efficient identification methods. This study aims to examine the relationship between distinct morphologic features-namely, squamous morules and squamous differentiation (SD), as well as β-catenin expression-and the POLE mutation status in endometrial cancer (EC). METHODS: Our study included 35 POLE-mutated (POLEmut) EC cases and 395 non-POLEmut EEC cases...
March 21, 2024: American Journal of Clinical Pathology
https://read.qxmd.com/read/38511852/how-do-i-the-academy-of-clinical-laboratory-physicians-and-scientists-aclps-publication-series
#20
JOURNAL ARTICLE
Amit A Gokhale
No abstract text is available yet for this article.
March 21, 2024: American Journal of Clinical Pathology
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