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September 22, 2023: American Journal of Clinical Pathology
#2
JOURNAL ARTICLE
Anastasia Gant Kanegusuku, Kiang-Teck J Yeo
OBJECTIVES: This study evaluated the suitability and accuracy of the automated Roche Elecsys tacrolimus electrochemiluminescence immunoassay (ECLIA) by comparing it with a current laboratory-developed test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). METHODS: The tacrolimus ECLIA was evaluated for precision, linearity, interference, and postextraction stability. Accuracy was compared with LC-MS/MS. RESULTS: The tacrolimus ECLIA assay is precise, exhibits a measuring range of 0...
September 19, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Yi Xiao, Mandy Palmucc, Lance Carlin, Catherine Lee, Maurice R G O'Gorman, Srikumar Nair, Leah Yieh, Edward Ki-Yun Leung
OBJECTIVES: Critical hyperbilirubinemia in preterm neonates, a condition requiring greater attention, is treated with phototherapy or exchange transfusion when bilirubin results exceed gestational age and age-specific medical decision levels (MDLs) to prevent bilirubin-induced neurologic damage. Conventional evaluation involves multiple manual steps and is poised to inconsistencies and delays. METHODS: We designed and implemented an electronic clinical decision support (CDS) tool to identify and alert neonatal intensive care unit clinicians of critical hyperbilirubinemia with a SmartZone alert...
September 12, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Ozgur Can Eren, Cisel Aydin Mericoz, Emine Bozkurtlar, Pinar Bulutay, Arzu Baygul, Ibrahim Kulac
OBJECTIVES: We present the first study validating the recent Dako ALK assay (clone OTI1A4, in vitro diagnostic) for detecting ALK rearrangements in lung adenocarcinoma. METHODS: Lung adenocarcinoma cases between 2011 and 2023 were retrospectively collected to create a cohort of 203 samples. Cases were stained with Dako ALK OTI1A4 and Ventana ALK D5F3 and reviewed by 3 pathologists independently. Correlation between assays, including their sensitivity and specificity, was evaluated...
September 8, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Robert C Benirschke, Joshua Wodskow, Kritika Prasai, Andrew Freeman, John M Lee, John Groth
OBJECTIVES: To assess the utility and performance of the large language model ChatGPT 4.0 regarding accuracy, completeness, and its potential as a time-saving tool for pathologists and laboratory directors. METHODS: A deidentified database of questions previously sent to pathology residents from health care providers was used as a source of general knowledge-type pathology questions. These questions were submitted to the large language model and the responses graded by subject matter experts in different pathology subspecialties...
September 2, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Fabio Del Ben, Giacomo Da Col, Doriana Cobârzan, Matteo Turetta, Daniela Rubin, Patrizio Buttazzi, Antonio Antico
OBJECTIVES: This article addresses the need for effective screening methods to identify negative urine samples before urine culture, reducing the workload, cost, and release time of results in the microbiology laboratory. We try to overcome the limitations of current solutions, which are either too simple, limiting effectiveness (1 or 2 parameters), or too complex, limiting interpretation, trust, and real-world implementation ("black box" machine learning models). METHODS: The study analyzed 15,312 samples from 10,534 patients with clinical features and the Sysmex Uf-1000i automated analyzer data...
September 2, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Marie-France Gagnon, Sally M Midthun, James A Fangel, Cynthia M Schuh, Ivy M Luoma, Kathryn E Pearce, Reid G Meyer, Sikander Ailawadhi, Mariano J Arribas, Esteban Braggio, Rafael Fonseca, S Vincent Rajkumar, Cinthya Zepeda-Mendoza, Xinjie Xu, Patricia T Greipp, Michael M Timm, Gregory E Otteson, Min Shi, Dragan Jevremovic, Horatiu Olteanu, Jess F Peterson, Rhett P Ketterling, Shaji Kumar, Linda B Baughn
OBJECTIVES: Fluorescence in situ hybridization (FISH) for plasma cell neoplasms (PCNs) requires plasma cell (PC) identification or purification strategies to optimize results. We compared the efficacy of cytoplasmic immunoglobulin FISH (cIg-FISH) and fluorescence-activated cell sorting FISH (FACS-FISH) in a clinical laboratory setting. METHODS: The FISH analysis results of 14,855 samples from individuals with a suspected PCN subjected to cytogenetic evaluation between 2019 and 2022 with cIg-FISH (n = 6917) or FACS-FISH (n = 7938) testing were analyzed...
September 2, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Anandi Lobo, Sourav K Mishra, Shilpy Jha, Ankit Tiwari, Rahul Kapoor, Shivani Sharma, Seema Kaushal, N Sri Kiranmai, M Rakshitha Das, Kamal P Peddinti, Shailendra K Sharma, Nitin Bhardwaj, Samriti Arora, Deepika Jain, Ekta Jain, Gauri Munjal, Sayali Shinde, Vipra Malik, Hena Singh, Juhi Varshney, Dinesh Pradhan, Mallika Dixit, Niharika Pattnaik, Ashish K Sharma, Yogesh R Barapatre, Manas Pradhan, Kaliprasad Satapathy, Debadarshi Rath, Sunil Jaiswal, Stithi Das, Chiraranjan Khadenga, Sudhasmita Routa, Manas R Baisakh, Romila Tiwari, Nakul Y Sampat, Indranil Chakrabarti, Anil V Parwani, Sambit K Mohanty
OBJECTIVES: Penile squamous cell carcinomas (PCs) are rare malignancies with a dismal prognosis in a metastatic setting; therefore, novel immunotherapeutic modalities are an unmet need. One such modality is the immune checkpoint molecule programmed cell death ligand 1 (PD-L1). We sought to analyze PD-L1 expression and its correlation with various clinicopathologic parameters in a contemporary cohort of 134 patients with PC. METHODS: A cohort of 134 patients with PC was studied for PD-L1 immunohistochemistry...
August 28, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Matthew D Ho, Kiang-Teck J Yeo, Scott E Eggener
No abstract text is available yet for this article.
August 28, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Charisse Liz B Treece, Jennifer Filipek, Jitin Makker, Neda A Moatamed, Erika F Rodriguez
OBJECTIVES: Intrapathology consultation is recommended for complex cases during frozen section (FS) as routine practice. In our institution, solicited second opinions were traditionally provided by in-person consultation (IPC). Whole-slide imaging (WSI) was implemented in 2018 as an alternative but replaced by videoconferencing in 2020. Here, we assess the accuracy of remote FS consultation using these digital modalities vs IPC. METHODS: Gynecologic FS cases over a 4-year period overseen by 2 intraoperative consultants were grouped by consultation method: (1) IPC, (2) WSI, and (3) videoconferencing...
August 28, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Scott Jew, Marissa-Skye Goldwater, Sean Bujarski, Bernard Regidor, Marsiye Emamy-Sadr, Regina Swift, Benjamin Eades, Jonathan Said, James R Berenson
OBJECTIVES: Data regarding bone marrow (BM) sampling and cytogenetic testing rates for identification of translocation (11q13;14q32) and their changes over time in a multiple myeloma (MM) population are limited. We analyzed these metrics at a clinic specializing in the treatment of MM. METHODS: A total of 760 BM aspirate samples from 351 patients were collected between August 2004 and October 2021. We analyzed BM sampling statistics, cytogenetic testing frequency, and the incidence rates for the t(11;14) translocation in a single clinic specializing in the treatment of MM...
August 23, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Jacob R Sweeney, Daniel J Arenas, Danielle Fortuna, Rashmi Tondon, Emma E Furth
OBJECTIVES: To quantitatively measure liver biopsy adequacy requirements and the effect of a teaching intervention that uses a virtual biopsy platform. METHODS: A library of virtual liver biopsies was created using digital whole-slide, trichrome-stained tissue sections from liver resection material and QuPath image analysis software. Blinded participants staged fibrosis on the virtual biopsies before and after a teaching intervention. RESULTS: This platform both modeled adequacy requirements for cirrhosis diagnosis on biopsy material and measured the effect of a teaching intervention on participant performance...
August 20, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Jeremy W Jacobs, Thomas C Binns, Elizabeth Abels, Juan J Silva Campos, Ragaa Elkabbani, Anna Kress, Nataliya Sostin, Christopher A Tormey
OBJECTIVES: We describe 3 cases of red blood cell (RBC) autoantibodies with unusual apparent antigenic specificity and discuss the testing methodology and implications of these findings. METHODS: All immunohematologic testing, including ABO and RhD typing, antibody detection and identification, RBC antigen phenotyping and genotyping, direct antiglobulin tests, and elution studies were performed using standardized and validated methods and reagents. RESULTS: Three patients were found to have autoantibodies, which were originally presumed to be alloantibodies...
August 20, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Steven Christopher Smith, Sara E Wobker
No abstract text is available yet for this article.
August 17, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Saurav Chopra, Nathanael G Bailey
OBJECTIVES: Two new classifications of myeloid neoplasms have recently been published: the International Consensus Classification (ICC) and the 5th edition of the World Health Organization classification (WHO5). We sought to examine the real-world impact of dueling classifications on patient diagnoses. METHODS: Our institutional pathology database was searched, and 237 specimens with a diagnosis of myeloid neoplasia were randomly selected. For each case, a classification based on the WHO5 and the ICC was assigned...
August 17, 2023: American Journal of Clinical Pathology
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JOURNAL ARTICLE
Youley Tjendra, Darcy A Kerr, Carmen Gomez-Fernandez, Jaylou M Velez Torres
OBJECTIVES: TRPS1 is a new, sensitive marker for breast carcinoma (BC). Salivary glands and breasts are both exocrine glands; thus, their tumors may share similar morphology and immunophenotype. Among salivary gland-type BC, TRPS1 is reported to be positive in secretory carcinomas (SCs) but negative in acinic cell carcinomas (AciCCs) and most adenoid cystic carcinomas (AdCCs). A subset of salivary duct carcinomas (SDCs) is positive for TRPS1. Herein, we investigate TRPS1 immunohistochemical expression in salivary gland tumors (SGTs)...
August 11, 2023: American Journal of Clinical Pathology
#17
JOURNAL ARTICLE
Kartik Viswanathan, Katrina M Mansmann, Kimberly Workowski, Jeannette Guarner, Kimberly M Heiman, Daniel J Lubin
OBJECTIVES: Mpox is a viral disease caused by monkeypox, a highly contagious orthopoxvirus that resulted in a global outbreak beginning in spring 2022. Diagnosis is confirmed via polymerase chain reaction (PCR) testing of swabs from mucocutaneous lesions. Rare reports have documented the histologic changes of mpox lesions, but the cytologic features have not been described. We present the cytology findings of samples taken from swabs of mucocutaneous mpox lesions in 3 different patients...
August 11, 2023: American Journal of Clinical Pathology
#18
(no author information available yet)
No abstract text is available yet for this article.
August 10, 2023: American Journal of Clinical Pathology
#19
JOURNAL ARTICLE
Sean X Gu, Alexa J Siddon, Scott F Huntington, Dhanpat Jain
OBJECTIVES: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is historically associated with Helicobacter pylori (HP) infections in more than 80% of patients. However, the incidence of HP-negative MALT lymphoma has been increasing. The clinicopathologic features have not been well studied, and optimal management strategies remain unclear. METHODS: The pathology database was searched for primary gastric MALT lymphomas diagnosed from 2000 to 2017. The clinical data and the slides were reviewed...
August 9, 2023: American Journal of Clinical Pathology
#20
JOURNAL ARTICLE
Richard R Pacheco, Busem Binboga Kurt, Kemal Kosemehmetoglu, Aimi T Rothrock, Andrea Lightle, Mahmut Akgul
OBJECTIVES: Multinucleated tumor cells (MTCs) in clear cell renal cell carcinoma (ccRCC) are not well understood. METHODS: Our study included ccRCC cases in a single institution between 2010 and 2019. We classified MTC as MTC with degenerative atypia (MTCD), MTC with no anaplasia (MTCNA), and MTC with anaplasia (MTCA). Clinicopathologic characteristics and outcomes were compared between MTC groups. RESULTS: In all, 92 of 256 people (36%) with ccRCC had MTC...
August 9, 2023: American Journal of Clinical Pathology
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