journal
https://read.qxmd.com/read/39044724/from-allergy-to-oncology-targeting-il-4-to-boost-cancer-immunotherapy
#1
Filippo Consonni, Antonio Corsello, Francesco Pegoraro
No abstract text is available yet for this article.
July 24, 2024: Allergy
https://read.qxmd.com/read/39044721/characterising-the-allergic-fungal-rhinosinusitis-microenvironment-using-full-length-16s-rrna-gene-amplicon-sequencing-and-fungal-its-sequencing
#2
JOURNAL ARTICLE
J T Connell, G Bouras, K Yeo, K Fenix, C Cooksley, A Bassiouni, S Vreugde, P J Wormald, A J Psaltis
INTRODUCTION: Allergic fungal rhinosinusitis (AFRS) is a severe phenotype of chronic rhinosinusitis with nasal polyposis (CRSwNP), characterised by localised and exaggerated type 2 inflammation. While fungal antigenic stimulation of unregulated Th2-mediated inflammation is the core pathophysiological mechanism, the direct and synergistic role of bacteria in disease modification is a pervasive hypothesis. We set out to define the microenvironment of AFRS to elucidate virulent organisms that may be implicated in the pathophysiology of AFRS...
July 24, 2024: Allergy
https://read.qxmd.com/read/39044706/disease-modification-in-chronic-spontaneous-urticaria
#3
REVIEW
Marcus Maurer, Pavel Kolkhir, Manuel P Pereira, Frank Siebenhaar, Ellen Witte-Händel, Karl-Christian Bergmann, Hanna Bonnekoh, Thomas Buttgereit, Joachim W Fluhr, Stefan Frischbutter, Eva Maria Grekowitz, Leonie Herzog, Lea Alice Kiefer, Karoline Krause, Markus Magerl, Melba Muñoz, Sophia Neisinger, Nicole Nojarov, Samantha Prins, Polina Pyatilova, Aisté Ramanauskaité, Jörg Scheffel, Dorothea Terhorst-Molawi, Regina Treudler, Karsten Weller, Torsten Zuberbier, Martin Metz
Chronic spontaneous urticaria (CSU) is a debilitating, inflammatory skin condition characterized by infiltrating immune cells. Available treatments are limited to improving the signs and symptoms. There is an unmet need to develop therapies that target disease-driving pathways upstream of mast cell activation to inhibit or delay the progression of CSU and associated comorbidities. Here, we aim to define disease modification due to a treatment intervention and criteria that disease-modifying treatments (DMTs) must meet in CSU...
July 24, 2024: Allergy
https://read.qxmd.com/read/39036854/granulocytes-and-mast-cells-in-allergooncology-bridging-allergy-to-cancer-an-eaaci-position-paper
#4
JOURNAL ARTICLE
Mariona Pascal, Heather J Bax, Christoph Bergmann, Rodolfo Bianchini, Mariana Castells, Jitesh Chauhan, Leticia De Las Vecillas, Karin Hartmann, Elena Izquierdo Álvarez, Uta Jappe, Teodorikez-Wilfox Jimenez-Rodriguez, Edward Knol, Francesca Levi-Schaffer, Cristobalina Mayorga, Aurélie Poli, Frank Redegeld, Alexandra F Santos, Erika Jensen-Jarolim, Sophia N Karagiannis
Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research...
July 22, 2024: Allergy
https://read.qxmd.com/read/39034850/clinical-efficacy-of-tezepelumab-in-pre-selected-non-type-2-asthma-patients
#5
LETTER
T C Timothy Chin-See-Chong, J P M Johanna van der Valk, J A Janice Layhadi, M H Mohamed Shamji, J H Jasper Kappen
No abstract text is available yet for this article.
July 22, 2024: Allergy
https://read.qxmd.com/read/39033313/effects-of-dupilumab-on-quality-of-life-burden-in-refractory-type-2-high-unified-airway-disease
#6
LETTER
Kirsten E Stewart, Chris RuiWen Kuo, Rory Chan, Brian J Lipworth
No abstract text is available yet for this article.
July 20, 2024: Allergy
https://read.qxmd.com/read/39033312/elucidating-allergic-reaction-mechanisms-in-response-to-sars-cov-2-mrna-vaccination-in-adults
#7
JOURNAL ARTICLE
Mihir M Shah, Janice A Layhadi, Dennis E Hourcade, William T Fulton, Tiak Ju Tan, Diane Dunham, Iris Chang, Monica S Vel, Andrea Fernandes, Alexandra S Lee, James Liu, Prabhu S Arunachalam, Stephen J Galli, Scott D Boyd, Bali Pulendran, Mark M Davis, Ruth O'Hara, Helen Park, Lynne M Mitchell, Antonina Akk, Alexander Patterson, Maya R Jerath, Jennifer M Monroy, Zhen Ren, Peggy L Kendall, Stephen R Durham, Aleksandra Fedina, Bernhard F Gibbs, Ioana Agache, Sharon Chinthrajah, Sayantani B Sindher, Anja Heider, Cezmi A Akdis, Mohamed H Shamji, Christine T N Pham, Kari C Nadeau
BACKGROUND: During the COVID-19 pandemic, novel nanoparticle-based mRNA vaccines were developed. A small number of individuals developed allergic reactions to these vaccines although the mechanisms remain undefined. METHODS: To understand COVID-19 vaccine-mediated allergic reactions, we enrolled 19 participants who developed allergic events within 2 h of vaccination and 13 controls, nonreactors. Using standard hemolysis assays, we demonstrated that sera from allergic participants induced stronger complement activation compared to nonallergic subjects following ex vivo vaccine exposure...
July 20, 2024: Allergy
https://read.qxmd.com/read/39031017/mesenchymal-stromal-cells-effectively-limit-house-dust-mite-extract-induced-mixed-granulocytic-lung-inflammation
#8
LETTER
Marlena Tynecka, Adrian Janucik, Agnieszka Tarasik, Arkadiusz Zbikowski, Magdalena Niemira, Agnieszka Kulczynska-Przybik, Anna Zeller, Nino Stocker, Joanna Reszec-Gielazyn, Barbara Mroczko, Adam Kretowski, Cezmi A Akdis, Milena Sokolowska, Marcin Moniuszko, Andrzej Eljaszewicz
No abstract text is available yet for this article.
July 19, 2024: Allergy
https://read.qxmd.com/read/39021347/in-chronic-spontaneous-urticaria-increased-galectin-9-expression-on-basophils-and-eosinophils-is-linked-to-high-disease-activity-endotype-specific-markers-and-response-to-omalizumab-treatment
#9
JOURNAL ARTICLE
Jiang Ji, Minhui Tang, Yue Zhao, Chuqiao Zhang, Yu Shen, Bin Zhou, Cuiping Liu, Marcus Maurer, Qingqing Jiao
BACKGROUND: Galectin-9 (Gal-9) has been implicated in allergic and autoimmune diseases, but its role and relevance in chronic spontaneous urticaria (CSU) are unclear. OBJECTIVES: To characterize the role and relevance of Gal-9 in the pathogenesis of CSU. METHODS: We assessed 60 CSU patients for their expression of Gal-9 on circulating eosinophils and basophils as well as T cell expression of the Gal-9 receptor TIM-3, compared them with 26 healthy controls (HCs), and explored possible links with disease features including disease activity (urticaria activity score, UAS), total IgE, basophil activation test (BAT), and response to omalizumab treatment...
July 18, 2024: Allergy
https://read.qxmd.com/read/39011970/epithelial-barrier-theory-in-the-context-of-nutrition-and-environmental-exposure-in-athletes
#10
REVIEW
Walter Kistler, Michael Villiger, Beat Villiger, Duygu Yazici, Yagiz Pat, Yasutaka Mitamura, Sena Ardicli, Stephen Skolnick, Raja Dhir, Mübeccel Akdis, Kari Nadeau, Ismail Ogulur, Cezmi A Akdis
Exposure to toxic substances, introduced into our daily lives during industrialization and modernization, can disrupt the epithelial barriers in the skin, respiratory, and gastrointestinal systems, leading to microbial dysbiosis and inflammation. Athletes and physically active individuals are at increased risk of exposure to agents that damage the epithelial barriers and microbiome, and their extreme physical exercise exerts stress on many organs, resulting in tissue damage and inflammation. Epithelial barrier-damaging substances include surfactants and enzymes in cleaning products, laundry and dishwasher detergents, chlorine in swimming pools, microplastics, air pollutants such as ozone, particulate matter, and diesel exhaust...
July 16, 2024: Allergy
https://read.qxmd.com/read/39007417/allergenic-potency-of-various-foods-of-mammalian-origin-in-patients-with-%C3%AE-gal-syndrome
#11
JOURNAL ARTICLE
Marija Perusko, Jeanette Grundström, Maria Eldh, Annika Reinhardt, Verena Fuhrmann, Meltem Düzakin, Carl Hamsten, Maria Starkhammar, Danijela Apostolovic, Marianne van Hage
BACKGROUND: The α-Gal syndrome (AGS) is an emerging allergy to mammalian food caused by IgE-mediated reactions to the carbohydrate galactose-α-1,3-galactose (α-Gal). Mammalian food sources contain α-Gal, but the amount differs. The objective of this study was to investigate the allergenic potency of various foods of mammalian origin among AGS patients. METHODS: Twenty-six AGS patients were included. Food extracts from innards, lean meats, processed meat products, milk, and whey were analyzed...
July 15, 2024: Allergy
https://read.qxmd.com/read/39003594/differential-decline-of-sars-cov-2-specific-antibody-levels-innate-and-adaptive-immune-cells-and-shift-of-th1-inflammatory-to-th2-serum-cytokine-levels-long-after-first-covid-19
#12
JOURNAL ARTICLE
Bernhard Kratzer, Pia Gattinger, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Robert B Stieger, Al Nasar Ahmed Sehgal, Melanie Feichter, Kristina Borochova, Inna Tulaeva, Katharina Grabmeier-Pfistershammer, Peter A Tauber, Thomas Perkmann, Ingrid Fae, Sabine Wenda, Michael Kundi, Gottfried F Fischer, Rudolf Valenta, Winfried F Pickl
BACKGROUND: SARS-CoV-2 has triggered a pandemic and contributes to long-lasting morbidity. Several studies have investigated immediate cellular and humoral immune responses during acute infection. However, little is known about long-term effects of COVID-19 on the immune system. METHODS: We performed a longitudinal investigation of cellular and humoral immune parameters in 106 non-vaccinated subjects ten weeks (10 w) and ten months (10 m) after their first SARS-CoV-2 infection...
July 14, 2024: Allergy
https://read.qxmd.com/read/39003573/evolution-of-pathologic-b-cell-subsets-and-serum-environment-specific-siges-in-patients-with-atopic-dermatitis-and-controls-from-infancy-to-adulthood
#13
JOURNAL ARTICLE
Tali Czarnowicki, Eden David, Kazuhiko Yamamura, Joseph Han, Helen He, Ana B Pavel, Jacob Glickman, Taylor Erickson, Yeriel Estrada, James G Krueger, Stephanie M Rangel, Amy S Paller, Emma Guttman-Yassky
BACKGROUND: While B-cells have historically been implicated in allergy development, a growing body of evidence supports their role in atopic dermatitis (AD). B-cell differentiation across ages in AD, and its relation to disease severity scores, has not been well defined. OBJECTIVE: To compare the frequency of B-cell subsets in blood of 0-5, 6-11, 12-17, and ≥18 years old patients with AD versus age-matched controls. METHODS: Flow cytometry was used to measure B-cell subset frequencies in the blood of 27 infants, 17 children, 11 adolescents, and 31 adults with moderate-to-severe AD and age-matched controls...
July 14, 2024: Allergy
https://read.qxmd.com/read/39003568/pyroptosis-gasdermins-and-allergic-diseases
#14
REVIEW
Ronald Allan Panganiban, Kari C Nadeau, Quan Lu
Pyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA-E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death. While much of the past research on pyroptosis has focused on its role in cancer, metabolic disorders, and infectious diseases, recent experimental and observational studies have begun to implicate pyroptosis in allergic diseases...
July 14, 2024: Allergy
https://read.qxmd.com/read/38995241/forecasting-daily-total-pollen-concentrations-on-a-global-scale
#15
JOURNAL ARTICLE
László Makra, Luca Coviello, Andrea Gobbi, Giuseppe Jurman, Cesare Furlanello, Mauro Brunato, Lewis H Ziska, Jeremy J Hess, Athanasios Damialis, Maria Pilar Plaza Garcia, Gábor Tusnády, Lilit Czibolya, István Ihász, Áron József Deák, Edit Mikó, Zita Dorner, Susan K Harry, Nicolas Bruffaerts, Ann Packeu, Annika Saarto, Linnea Toiviainen, Maria Louna-Korteniemi, Sanna Pätsi, Michel Thibaudon, Gilles Oliver, Athanasios Charalampopoulos, Despoina Vokou, Ewa Maria Przedpelska-Wasowicz, Ellý Renée Guðjohnsen, Maira Bonini, Sevcan Celenk, Cumali Ozaslan, Jae-Won Oh, Krista Sullivan, Linda Ford, Michelle Kelly, Estelle Levetin, Dorota Myszkowska, Elena Severova, Regula Gehrig, María Del Carmen Calderón-Ezquerro, César Guerrero Guerra, Manuel Andres Leiva-Guzmán, Germán Darío Ramón, Laura Beatriz Barrionuevo, Jonny Peter, Dilys Berman, Connie H Katelaris, Janet M Davies, Pamela Burton, Paul J Beggs, Sandra María Vergamini, Rosa María Valencia-Barrera, Claudia Traidl-Hoffmann
BACKGROUND: There is evidence that global anthropogenic climate change may be impacting floral phenology and the temporal and spatial characteristics of aero-allergenic pollen. Given the extent of current and future climate uncertainty, there is a need to strengthen predictive pollen forecasts. METHODS: The study aims to use CatBoost (CB) and deep learning (DL) models for predicting the daily total pollen concentration up to 14 days in advance for 23 cities, covering all five continents...
July 12, 2024: Allergy
https://read.qxmd.com/read/38993131/children-with-eosinophilic-esophagitis-non-responsive-to-combination-therapy-have-distinct-esophageal-transcriptomic-and-microbiome-profile
#16
JOURNAL ARTICLE
Girish Hiremath, Yash Choksi, Hernan Correa, Justin Jacobse, Suman R Das, Siyuan Ma, Jeremy A Goettel, Seesandra V Rajagopala
BACKGROUND: A combination of proton-pump inhibitors (PPI) and topical steroids (TS) is used to treat children with eosinophilic esophagitis (EoE). However, a subset of children do not respond to this combination therapy. We aimed to identify the esophageal transcriptional, cell composition, and microbial differences between the non-responders (EoE-PPI-TSnr; n = 7) and responders (EoE-PPI-TSr; n = 7) to the combination therapy for EoE and controls (n = 9) using metatranscriptomics...
July 12, 2024: Allergy
https://read.qxmd.com/read/38993120/alpine-altitude-climate-treatment-improves-asthma-control-irrespective-of-biologics-use
#17
LETTER
Karin B Fieten, Marieke T Drijver-Messelink, Rolf Wolters, Bart Hilvering, Susanne J H Vijverberg, Els J Weersink
No abstract text is available yet for this article.
July 12, 2024: Allergy
https://read.qxmd.com/read/38989779/allergen-specific-b-cell-responses-in-oral-immunotherapy-induced-desensitization-remission-and-natural-outgrowth-in-cow-s-milk-allergy
#18
JOURNAL ARTICLE
Pattraporn Satitsuksanoa, Willem van de Veen, Ge Tan, Juan-Felipe Lopez, Oliver Wirz, Kirstin Jansen, Milena Sokolowska, David Mirer, Anna Globinska, Tadech Boonpiyathad, Stephan R Schneider, Elena Barletta, Hergen Spits, Iris Chang, Huseyn Babayev, İlhan Tahralı, Gunnur Deniz, Esra Özek Yücel, Ayca Kıykım, Scott D Boyd, Cezmi A Akdis, Kari Nadeau, Mübeccel Akdis
BACKGROUND: Antigen-specific memory B cells play a key role in the induction of desensitization and remission to food allergens in oral immunotherapy and in the development of natural tolerance (NT). Here, we characterized milk allergen Bos d 9-specific B cells in oral allergen-specific immunotherapy (OIT) and in children spontaneously outgrowing cow's milk allergy (CMA) due to NT. METHODS: Samples from children with CMA who received oral OIT (before, during, and after), children who naturally outgrew CMA (NT), and healthy individuals were received from Stanford biobank...
July 11, 2024: Allergy
https://read.qxmd.com/read/38987868/childhood-infections-asthma-and-allergy-trajectories-and-chronic-rhinosinusitis-in-middle-age-a-prospective-cohort-study-across-six-decades
#19
JOURNAL ARTICLE
Jennifer L Perret, N Sabrina Idrose, E Haydn Walters, Dinh S Bui, Adrian J Lowe, Caroline J Lodge, Anne R Fernandez, Vivian Yao, Iain Feather, Xiao-Wen Zeng, Bruce R Thompson, Bircan Erbas, Michael J Abramson, Shyamali C Dharmage
INTRODUCTION: Evidence on the early life risk factors of adult CRS, and the history of asthma and allergies across the life course, is limited. AIM: To investigate relationships between respiratory infective/allergic conditions in childhood, and asthma and allergies across the life course and CRS in middle age. METHODS: Data were from the population-based Tasmanian Longitudinal Health Study (TAHS) cohort, first studied in 1968 when aged 6-7 years (n = 8583) and serially followed into middle age (n = 3609)...
July 10, 2024: Allergy
https://read.qxmd.com/read/38979807/anti-rubella-igg-serum-levels-predict-risk-for-sars-cov-2-breakthrough-infections
#20
LETTER
Moritz M Hollstein, Sascha Dierks, Michael P Schön, Uwe Groß, Karin Thiele, Andreas Leha, Andreas E Zautner, Andreas Fischer, Luise Erpenbeck, Moritz Schnelle
No abstract text is available yet for this article.
July 9, 2024: Allergy
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