journal
MENU ▼
Read by QxMD icon Read
search

Allergy

journal
https://read.qxmd.com/read/31004501/what-did-we-learn-from-multiple-omics-studies-in-asthma
#1
REVIEW
Olga Ivanova, Levi B Richards, Susanne J Vijverberg, Anne H Neerincx, Anirban Sinha, Peter J Sterk, Anke H Maitland van der Zee
More than a decade has passed since the finalisation of the Human Genome Project. Omics technologies made a huge leap from trendy and very expensive to routinely executed and relatively cheap assays. Simultaneously, we understood that omics is not a panacea for every problem in the area of human health and personalized medicine. Whilst in some areas of research omics showed immediate results, in other fields, including asthma, it only allowed us to identify the incredibly complicated molecular processes. Along with their possibilities, omics technologies also bring many issues connected to sample collection, analyses and interpretation...
April 20, 2019: Allergy
https://read.qxmd.com/read/31004499/a-new-ige-western-blot-identifies-aspergillus-fumigatus-sensitization-and-may-discriminate-allergic-bronchopulmonary-aspergillosis
#2
LETTER
Raphaël Piarroux, Jean-Christophe Dubus, Martine Reynaud-Gaubert, Marion Gouitaa, Stéphane Ranque, Joana Vitte
No abstract text is available yet for this article.
April 20, 2019: Allergy
https://read.qxmd.com/read/31004495/endothelial-b2-receptor-overexpression-as-an-alternative-animal-model-for-hereditary-angioedema
#3
LETTER
Camila Lopes Veronez, Sara Maghsodi, Mihail Todiras, Elena Popova, André Felipe Rodrigues, Fatimunnisa Qadri, João Bosco Pesquero, Michael Bader
No abstract text is available yet for this article.
April 20, 2019: Allergy
https://read.qxmd.com/read/31004440/the-allergen-specificity-of-allergen-immunotherapy-doubt-no-more
#4
EDITORIAL
Stephen R Durham
The ARIA-GA2LEN collaboration published a guide for the design and evaluation of randomised controlled trials of allergen immunotherapy for allergic rhinitis. Several problems in were identified. For example, the severity/persistence of seasonal symptoms in subjects during allergen immunotherapy was noted to be much lower than in trials of pharmacotherapy. The drop-out rates were higher. Seasonal pollen counts varied markedly between study centres and year-on-year during long-term trials thereby confounding the ability to detect treatment effects during 'low' pollen seasons...
April 20, 2019: Allergy
https://read.qxmd.com/read/31002401/the-impact-of-prescribed-fire-versus-wildfire-on-the-immune-and-cardiovascular-systems-of-children
#5
LETTER
Mary Prunicki, Rodd Kelsey, Justin Lee, Xiaoying Zhou, Edward Smith, Francois Haddad, Joseph Wu, Kari Nadeau
No abstract text is available yet for this article.
April 19, 2019: Allergy
https://read.qxmd.com/read/30993703/medical-algorithm-diagnosis-and-treatment-of-chronic-rhinosinusitis
#6
Claus Bachert, Zhang Nan
Chronic rhinosinusitis (CRS) is a disease affecting more than 10% of the European population, causing symptoms and impacting quality of life. CRS is classically differentiated into disease without and with nasal polyps (CRSsNP, CRSwNP) based on clinical signs, specifically using nasal endoscopy for diagnosis (1). However, the differentiation into phenotypes allows to conclude on dominant remodelling patterns (fibrosis in CRSsNP or oedema and polyp formation in CRSwNP), but does only partly predict the natural course of disease; phenotypes do not adequately appreciate the current discussion about different surgical approaches or innovative biologics...
April 16, 2019: Allergy
https://read.qxmd.com/read/30989659/direct-assessment-of-skin-epithelial-barrier-by-electrical-impedance-spectroscopy
#7
Arturo O Rinaldi, Hideaki Morita, Paulina Wawrzyniak, Anita Dreher, Simon Grant, Per Svedenhag, Cezmi A Akdis
BACKGROUND: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy. METHODS: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping...
April 16, 2019: Allergy
https://read.qxmd.com/read/30985936/the-patient-needs-in-asthma-treatment-neat-questionnaire-further-evidence-on-its-psychometric-properties
#8
Julia Schreitmüller, Christian Apfelbacher, Aziz Sheikh, Adrian Loerbroks
BACKGROUND: Building on previous psychometric work, we sought to assess the Patient Needs in Asthma Treatment (NEAT) questionnaire's validity, responsiveness to change and the minimal important change (MIC) over a 3-year period (Study 1) and its reliability and the smallest detectable change (SDC) in a test-retest-study (Study 2) among patients self-reporting physician-diagnosed asthma. METHODS: In Study 1, a total of 207 patients completed a survey which included the NEAT, the Asthma Control Test (ACT), the Asthma Quality of Life Questionnaire-Sydney (AQLQ-S) and a question on treatment satisfaction in 2014 and 2017...
April 15, 2019: Allergy
https://read.qxmd.com/read/30982974/benzo-a-pyrene-facilitates-dermatophagoides-group-1-der-f-1-induced-epithelial-cytokine-release-through-aryl-hydrocarbon-receptor-in-asthma
#9
E Wang, X Liu, W Tu, D C Do, H Yu, L Yang, Y Zhou, D Xu, S K Huang, P Yang, P Ran, P Gao, Z Liu
BACKGROUND: Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co-exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1-induced asthma and its underlying mechanisms. METHODS: The effect of BaP was investigated in Der f 1-induced mouse model of asthma, including airway hyper-responsiveness, allergic inflammation, and epithelial-derived cytokines...
April 14, 2019: Allergy
https://read.qxmd.com/read/30972798/diagnosis-and-treatment-of-hymenoptera-venom-allergy
#10
Gunter J Sturm, Lisa Arzt-Gradwohl, Eva-M Varga
Diagnosis of Hymenoptera venom allergy (HVA) is straightforward in the majority of patients, but can be challenging in double positive and test negative patients. Test results sometimes can be confusing as patients with high skin test reactivity and high specific IgE (sIgE) levels are not at risk for severe systemic sting reactions (SSR), and conversely, patients with weakly positive or even negative tests can experience severe SSR. Venom immunotherapy (VIT) is safe, highly effective and recommended in patients with moderate to severe SSR and in patients with SSR confined to generalized skin symptoms if quality of life is impaired...
April 11, 2019: Allergy
https://read.qxmd.com/read/30972788/hla-b-57-01-confers-genetic-susceptibility-to-carbamazepine-induced-sjs-ten-in-europeans
#11
LETTER
Maja Mockenhaupt, Chuang-Wei Wang, Shuen-Iu Hung, Peggy Sekula, Alexander H Schmidt, Ren-You Pan, Chun-Bing Chen, Ariane Dunant, Sabine Le Gouvello, Martin Schumacher, Laurence Valeyrie-Allanore, Teresa Bellon, Sylvia H Kardaun, Yun-Shen Jan, Wen-Hung Chung, Jean-Claude Roujeau
No abstract text is available yet for this article.
April 11, 2019: Allergy
https://read.qxmd.com/read/30972786/na%C3%A3-ve-regulatory-t-cells-in-infancy-associations-with-perinatal-factors-and-development-of-food-allergy
#12
F Collier, A L Ponsonby, M O'Hely, M L K Tang, R Saffery, J Molloy, L E Gray, S Ranganathan, D Burgner, Katrina J Allen, S Brix, P Vuillermin
BACKGROUND: In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However longitudinal studies, that account for relevant perinatal factors, are required. The aim of this study was to investigate the relationship between perinatal factors, naïve Treg (nTreg) over the first postnatal year, and development of food allergy. METHODS: In a birth cohort (n=1074), the proportion of nTreg in the CD4+ T-cell compartment was measured by flow cytometry at birth (n=463), six (n=600) and twelve (n=675) months...
April 11, 2019: Allergy
https://read.qxmd.com/read/30972779/we-are-still-confused-but-on-a-higher-level
#13
EDITORIAL
Matthias Wjst
The vitamin D world is deeply split about the clinical usefulness of serum vitamin D (25-OH-D3 ) measurements. Basic discoveries of vitamin D research provided stunning results while clinical and epidemiological research resulted in a barrel of misunderstandings and contradictions. Vitamin D is easy to measure but the results are difficult to interpret. This article is protected by copyright. All rights reserved.
April 11, 2019: Allergy
https://read.qxmd.com/read/30972799/lung-eosinophils-a-novel-virus-sink-that-is-defective-in-asthma
#14
EDITORIAL
Milos Jesenak, Jürgen Schwarze
Eosinophils represent one of the most studied cells in the development and pathophysiology of various immune mediated disorders and conditions. Moreover, they serve as important biomarkers (diagnostic, therapy-driving, prognostic) in daily allergy praxis and can be affected by several therapeutic interventions.1 Eosinophils differentiate from a pluripotent progenitor under the influence of several cytokines and growth factors. Amongst these, interleukin-5 (IL-5) seems to be critical for eosinophil differentiation and maturation in the bone marrow...
April 10, 2019: Allergy
https://read.qxmd.com/read/30964950/langerhans-cells-mediate-the-skin-induced-tolerance-to-ovalbumin-via-langerin-in-a-murine-model
#15
Yang Luo, Su Wang, Xiaochun Liu, He Wen, Wei Li, Xu Yao
BACKGROUND: Epicutaneous sensitization is an important route of immunization for allergens in atopic diseases; however, studies have also shown that application with protein on intact skin induces antigen-specific tolerance. Langerhans cells (LCs) play an immunosuppressive role in several inflammatory skin diseases and mouse models, and the role of LCs in the skin-induced tolerance is not fully understood. METHODS: Langerin-DTA mice that were deficient in LCs were utilized to produce the model of skin-induced tolerance to ovalbumin (OVA)...
April 9, 2019: Allergy
https://read.qxmd.com/read/30964945/thinking-bigger-how-early-life-environmental-exposures-shape-the-gut-microbiome-and-influence-the-development-of-asthma-and-allergic-disease
#16
REVIEW
Hind Sbihi, Rozlyn C T Boutin, Chelsea Cutler, Mandy Suen, B Brett Finlay, Stuart E Turvey
Imbalance, or dysbiosis, of the gut microbiome of infants has been linked to an increased risk of asthma and allergic diseases. Most studies to date have provided a wealth of data showing correlations between early-life risk factors for disease and changes in the structure of the gut microbiome that disrupt normal immunoregulation. These studies have typically focused on one specific risk factor, such as mode of delivery or early-life antibiotic use. Such 'micro-level' exposures have a considerable impact on affected individuals but not necessarily the whole population...
April 9, 2019: Allergy
https://read.qxmd.com/read/30964557/periostin-an-emerging-biomarker-for-allergic-diseases
#17
REVIEW
Kenji Izuhara, Satoshi Nunomura, Yasuhiro Nanri, Junya Ono, Masayuki Takai, Atsushi Kawaguchi
Periostin is a matricellular protein as well as an extracellular matrix (ECM) protein belonging to the fasciclin family. Periostin plays important roles as a matricellular protein in the setting of allergic diseases by binding to several integrins on various cells. Since periostin is induced mainly by IL-4 and IL-13, signature type 2 cytokines, and it is highly expressed in the subepithelial regions of many chronic allergic diseases, periostin has emerged as a novel biomarker reflecting type 2 inflammation in allergic diseases...
April 9, 2019: Allergy
https://read.qxmd.com/read/30964555/an-eaaci-position-paper-on-the-investigation-of-perioperative-immediate-hypersensitivity-reactions
#18
L H Garvey, D G Ebo, P M Mertes, P Dewachter, T Garcez, P Kopac, J J Laguna, A Chiriac, I Terreehorst, S Voltolini, K Scherer
Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized and it is becoming increasingly apparent that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients...
April 9, 2019: Allergy
https://read.qxmd.com/read/30964550/allergooncology-expression-platform-development-and-functional-profiling-of-an-anti-her2-ige-antibody
#19
LETTER
Kristina M Ilieva, Judit Fazekas-Singer, Heather J Bax, Silvia Crescioli, Laura Montero-Morales, Silvia Mele, Heng Sheng Sow, Chara Stavraka, Debra H Josephs, James F Spicer, Herta Steinkellner, Erika Jensen-Jarolim, Andrew N J Tutt, Sophia N Karagiannis
No abstract text is available yet for this article.
April 9, 2019: Allergy
https://read.qxmd.com/read/30964546/legends-of-allergology-dietrich-kraft
#20
Heimo Breiteneder
The term allergy was coined in 1906 by the Austrian scientist and paediatrician Clemens Freiherr von Pirquet, head of the Department of Paediatrics in Vienna from 1912 to 1929. His successor, Franz Hamburger, obliterated all references to Pirquet, especially the term allergy, creating a large gap in allergy research until the 1960s. The University of Vienna Dermatology and ENT departments performed skin prick tests and hyposensitizations well into the late 1970s, but no basic scientific research was done. Dietrich Kraft re-established allergy research in Austria on the basis of molecular biology...
April 9, 2019: Allergy
journal
journal
20009
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"