journal
https://read.qxmd.com/read/38227571/different-effects-of-the-companion-antiretroviral-drugs-on-dolutegravir-trough-concentrations-a-focus-on-novel-dual-regimens
#141
JOURNAL ARTICLE
Dario Cattaneo, Simone Pagano, Martina Laura Colombo, Andrea Giacomelli, Andrea Gori, Cristina Gervasoni
BACKGROUND: Dolutegravir is widely used in different dual and triple antiretroviral regimens. Here, we sought to investigate the effect of the companion antiretroviral drug(s) on dolutegravir plasma trough concentrations in persons with HIV, with a focus on dual regimens. METHODS: Dolutegravir concentrations collected from October 2015 to March 2023 (n = 900) were stratified according to the main antiretroviral classes (NRTIs, NNRTIs, PIs) and according to single drugs...
January 16, 2024: AIDS
https://read.qxmd.com/read/38227572/comparison-of-hiv-prevalence-incidence-and-viral-load-suppression-in-zambia-population-based-hiv-impact-assessments-from-2016-and-2021
#142
JOURNAL ARTICLE
Lloyd B Mulenga, Jonas Z Hines, Kristen A Stafford, Kumbutso Dzekedzeke, Suilanji Sivile, Brianna Lindsay, Mumbi Chola, Faith Ussery, Hetal K Patel, Alash'le Abimiku, Sehin Birhanu, Peter Minchella, Thomas Stevens, Brave Hanunka, Tina Chisenga, Aaron Shibemba, Sombo Fwoloshi, Mwiche Siame, John Mutukwa, Lameck Chirwa, Mpanji Siwingwa, Gina Mulundu, Chinedu Agbakwuru, Prichard Mapondera, Mervi Detorio, Simon G Agolory, Mwaka Monze, Megan Bronson, Man E Charurat
BACKGROUND: The Zambian government has implemented a public health response to control the HIV epidemic in the country. Zambia conducted a population-based HIV impact assessment (ZAMPHIA) survey in 2021 to assess the status of the HIV epidemic to guide its public health programs. METHODS: ZAMPHIA 2021 was a cross-sectional two-stage cluster sample household survey among persons aged ≥15 years conducted in Zambia across all 10 provinces. Consenting participants were administered a standardized questionnaire and whole blood was tested for HIV according to national guidelines...
January 15, 2024: AIDS
https://read.qxmd.com/read/38224361/mediation-analysis-of-ckd-risk-factors-using-kidney-biomarkers-in-women-living-with-hiv
#143
JOURNAL ARTICLE
Kristienne A Edrosolan, Michael G Shlipak, Rebecca Scherzer, Michelle M Estrella, Deborah Gustafson, Roksana Karim, Molly Fisher, Mardge Cohen, Seble Kassaye, Julie Dumond, Alison Abraham, Charles E Mcculloch, Simon B Ascher
OBJECTIVE: Novel urinary biomarkers reflecting kidney tubule health are associated with chronic kidney disease (CKD) risk in persons living with HIV. However, it is unknown whether these biomarkers provide mechanistic insight into the associations between clinical risk factors for CKD and subsequent CKD risk. METHODS: Among 636 women living with HIV in the Women's Interagency HIV Study with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2, we used a counterfactual approach to causal mediation analysis to evaluate the extent to which systolic blood pressure (SBP), diastolic blood pressure (DBP), hemoglobin a1c (Hba1c) and serum albumin associations with incident CKD were mediated by eight urine proteins...
January 15, 2024: AIDS
https://read.qxmd.com/read/38224350/effects-of-covid-19-mrna-vaccination-on-hiv-viremia-and-reservoir-size
#144
JOURNAL ARTICLE
Maggie C Duncan, F Harrison Omondi, Natalie N Kinloch, Hope R Lapointe, Sarah Speckmaier, Nadia Moran-Garcia, Tanya Lawson, Mari L DeMarco, Janet Simons, Daniel T Holmes, Christopher F Lowe, Nic Bacani, Paul Sereda, Rolando Barrios, Marianne Harris, Marc G Romney, Julio S G Montaner, Chanson J Brumme, Mark A Brockman, Zabrina L Brumme
OBJECTIVE: The immunogenic nature of COVID-19 mRNA vaccines led to some initial concern that these could stimulate the HIV reservoir. We analyzed changes in plasma HIV loads (pVL) and reservoir size following COVID-19 mRNA vaccination in 62 people with HIV (PWH) receiving antiretroviral therapy (ART), and analyzed province-wide trends in pVL before and after the mass vaccination campaign. DESIGN: Longitudinal observational cohort and province-wide analysis. METHODS: 62 participants were sampled pre-vaccination, and one month after their first and second COVID-19 immunizations...
January 15, 2024: AIDS
https://read.qxmd.com/read/38669203/the-impact-of-hiv-pre-exposure-prophylaxis-on-bacterial-sexually-transmitted-infection-occurrence-in-msm-a-systematic-review-and-meta-analysis
#145
JOURNAL ARTICLE
Nikolaos Georgiadis, Dimitrios Papamichail, Theodore Lytras, Perry N Halkitis, Georgina Tzanakaki, Eleni Kornarou, Nair-Tonia Vassilakou, Theodoros N Sergentanis
OBJECTIVE: To evaluate the effect of preexposure prophylaxis (PrEP) initiation on bacterial sexually transmitted infection (STI) occurrence (overall; chlamydia; gonorrhea; syphilis), in MSM. DESIGN: Systematic review and meta-analysis. METHODS: Systematic searches were performed in PubMed, Embase, and Scopus without language restrictions until 1 February 2023. We sought studies reporting data for the estimation of incidence rate ratios (IRR), prevalence ratios or cumulative incidence ratios (the latter in equal time periods before and after PrEP initiation) regarding bacterial STI occurrence...
January 12, 2024: AIDS
https://read.qxmd.com/read/38381717/hiv-viral-suppression-in-children-and-adolescents-two-years-after-transition-to-dolutegravir-a-multicentre-cohort-study
#146
JOURNAL ARTICLE
Akash Devendra, Maurus Kohler, Motlatsi Letsika, Hape Khooa, Lipontso Motaboli, Malebanye Lerotholi, Nadine Tschumi, Niklaus D Labhardt, Jennifer A Brown
BACKGROUND: Treatment failure is common among children and adolescents with HIV. Antiretroviral therapy (ART) containing dolutegravir has recently been rolled out across Africa, though long-term real-world data in paediatric populations are lacking. Here, we report treatment outcomes among children and adolescents in Lesotho who transitioned from non-nucleoside reverse transcriptase inhibitor- (NNRTI-) to dolutegravir-based ART through two years' follow-up. METHODS: Data were derived from two open cohort studies in Lesotho...
January 10, 2024: AIDS
https://read.qxmd.com/read/38194697/how-the-covid-19-pandemic-and-the-health-system-s-response-reduced-hiv-testing-and-increased-late-diagnoses-in-mexico
#147
JOURNAL ARTICLE
Fernando Macías-González, Heleen Vermandere, Alicia Piñeirúa-Menendez, Sergio Bautista-Arredondo
OBJECTIVES: This study aims to evaluate the disruption in HIV screening and diagnoses due to the COVID-19 pandemic and to investigate the pandemic's subsequent influence on the HIV epidemic. DESIGN: A retrospective examination of testing and confirmed diagnoses time series was undertaken from 2011 to 2022. The analysis encompassed testing, positive tests, positivity rates, and diagnosis outcomes, including new HIV diagnoses, asymptomatic HIV diagnoses, and symptomatic HIV diagnoses...
January 9, 2024: AIDS
https://read.qxmd.com/read/38194696/statin-therapy-is-underutilized-in-people-with-hiv-who-could-benefit-from-targeted-lipid-lowering-interventions
#148
JOURNAL ARTICLE
Iulia Filip
No abstract text is available yet for this article.
January 9, 2024: AIDS
https://read.qxmd.com/read/38181069/covid-related-excess-missed-hiv-diagnoses-in-the-united-states-in-2021-follow-up-to-2020
#149
JOURNAL ARTICLE
Alex Viguerie, Ruiguang Song, Anna Satcher Johnson, Cynthia M Lyles, Angela Hernandez, Paul G Farnham
OBJECTIVE: :COVID-19 and related disruptions led to a significant decline in HIV diagnoses in the US in 2020. A previous analysis estimated 18% fewer diagnoses than expected among persons with HIV (PWH) acquiring infection in 2019 or earlier, suggesting that the decline in overall diagnoses cannot be attributed solely to decreased transmission. This analysis evaluates the progress made towards closing the 2020 diagnosis deficit in 2021. METHODS: :We apply previously developed methods analyzing 2021 diagnosis data from the National HIV Surveillance System to determine whether 2021 diagnosis levels of PWH infected pre2020 are above or below the expected pre-COVID trends...
January 5, 2024: AIDS
https://read.qxmd.com/read/38181091/evaluation-of-the-prevention-of-mother-to-child-transmission-of-hiv-programs-at-the-second-immunization-visit-in-burkina-faso-and-zambia
#150
JOURNAL ARTICLE
Souleymane Tassembedo, Mwiya Mwiya, Anais Mennecier, Chipepo Kankasa, Paulin Fao, Jean Pierre Molès, Dramane Kania, Catherine Chunda-Liyoka, Leticia Delphine Sakana, Morgana D'Ottavi, Ajani Ousmane Taofiki, David Rutagwera, M M Wilfried-Tonga, Thorkild Tylleskär, Nicolas Nagot, Philippe Van De Perre
OBJECTIVE: Our study aimed to assess the PMTCT indicators in Burkina Faso and Zambia using a patient-orientated innovative strategy based on the second visit in the Expanded Program on Immunization (EPI-2) visit at 6-8 weeks. DESIGN: This was a cross sectional study. METHODS: We assessed women attending EPI-2 at primary healthcare facilities in Burkina Faso and Zambia with their children about their exposure to PMTCT interventions. For women living with HIV (WLHIV), viral load was measured and their children were tested for HIV DNA using point of care devices...
January 4, 2024: AIDS
https://read.qxmd.com/read/38061025/effect-of-influenza-vaccination-on-the-persistence-of-hiv-reservoirs-and-immunologic-parameters-in-people-with-hiv
#151
JOURNAL ARTICLE
Jana Blazkova, Victoria Shi, Maegan R Manning, Brooke D Kennedy, J Shawn Justement, Lauren Praiss, Kathleen Gittens, Catherine A Seamon, M Ali Rai, Susan Moir, Tae-Wook Chun
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/38061024/exacerbation-of-kaposi-sarcoma-after-mva-bn-jynneos-vaccination-in-a-person-with-hiv-aids
#152
JOURNAL ARTICLE
Patricia Volkow, Beda Islas-Muñoz, Daniel Carpio-Guadarrama, Rogelio Pérez-Padilla
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/38061023/use-of-a-machine-learning-model-to-predict-retention-in-care-in-an-urban-hiv-clinic
#153
JOURNAL ARTICLE
Sarah A Schmalzle, Demetri Maroosis, Henry Masur, Shyam Kottilil, Poonam Mathur
Identifying barriers to retention in care (RIC) is critical to ending the HIV epidemic in the United States. Therefore, we developed a machine learning model (MLM) to identify predictive factors for RIC in an urban HIV clinic. Our MLM yielded a positive predictive value of 84%, higher than previously reported MLMs. We found that MLM can be used to develop interventional strategies to enhance RIC in HIV care.
January 1, 2024: AIDS
https://read.qxmd.com/read/38061022/measles-seroprevalence-in-adolescents-and-young-adults-living-with-hiv-and-response-to-mmr-booster-in-seronegative-ones
#154
JOURNAL ARTICLE
Raquel M Simakawa, Beatriz C Araújo, Erika Ono, M Isabel De Moraes-Pinto, Regina C M Succi
OBJECTIVE: The study analyzed people with HIV (PWH) measles seroprevalence and response to MMR booster given to seronegative individuals. DESIGN: A prospective cohort study with four groups: vertically (v-HIV), horizontally infected (h-HIV) individuals, and two control groups. An MMR booster was offered to seronegative individuals. RESULTS: Measles seropositivity and IgG antibodies were significantly lower in v-HIV than in the other groups...
January 1, 2024: AIDS
https://read.qxmd.com/read/38061021/predicting-tuberculosis-at-antiretroviral-therapy-initiation-the-combination-of-monocyte-to-lymphocyte-ratio-and-hemoglobin-level-may-be-a-key
#155
JOURNAL ARTICLE
Tetsuo Tsukamoto, Dean L Winslow
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/38061020/aids-changes-in-leadership
#156
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/38016159/ending-the-hiv-epidemic-in-the-united-states-lessons-from-eswatini
#157
JOURNAL ARTICLE
Jessica Justman, Connor Wright, Wafaa M El-Sadr
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/37962215/short-term-weight-gain-after-antiretroviral-therapy-initiation-may-have-long-term-consequences
#158
JOURNAL ARTICLE
Iulia Filip
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/37939141/a-study-of-the-pharmacokinetics-safety-and-efficacy-of-bictegravir-emtricitabine-tenofovir-alafenamide-in-virologically-suppressed-pregnant-women-with-hiv
#159
MULTICENTER STUDY
Haeyoung Zhang, Jason T Hindman, Ludwig Lin, Maggie Davis, Justin Shang, Deqing Xiao, Anchalee Avihingsanon, Priyanka Arora, Ramesh Palaparthy, Sandhya Girish, Dhananjay D Marathe
OBJECTIVE: The objective of this study was to assess the pharmacokinetics, safety, and efficacy and confirm the dose of once-daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF; B/F/TAF) during pregnancy. DESIGN: An open-label, multicenter, single-arm, phase 1b study (NCT03960645) was conducted in 33 virologically suppressed pregnant women with HIV-1. METHODS: Participants received B/F/TAF (50/200/25 mg) from the second or third trimester through ∼16 weeks postpartum...
January 1, 2024: AIDS
https://read.qxmd.com/read/37788108/impact-of-a-livelihood-intervention-on-gender-roles-and-relationship-power-among-people-with-hiv
#160
RANDOMIZED CONTROLLED TRIAL
Lila A Sheira, Pauline Wekesa, Craig R Cohen, Elly Weke, Edward A Frongillo, A Rain Mocello, Shari L Dworkin, Rachel L Burger, Sheri D Weiser, Elizabeth A Bukusi
OBJECTIVE: To evaluate the impact of an agricultural livelihood intervention on gender role conflict and sexual relationship power among people with HIV (PWH) in western Kenya. DESIGN: Study participants were enrolled in Shamba Maisha , a cluster randomized controlled trial of an agricultural intervention conducted among PWH across 16 health facilities during 2016-2020. Intervention participants received a water pump, seeds, and agricultural and financial training; control participants received standard of HIV care...
January 1, 2024: AIDS
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