journal
https://read.qxmd.com/read/38061022/measles-seroprevalence-in-adolescents-and-young-adults-living-with-hiv-and-response-to-mmr-booster-in-seronegative-ones
#121
JOURNAL ARTICLE
Raquel M Simakawa, Beatriz C Araújo, Erika Ono, M Isabel De Moraes-Pinto, Regina C M Succi
OBJECTIVE: The study analyzed people with HIV (PWH) measles seroprevalence and response to MMR booster given to seronegative individuals. DESIGN: A prospective cohort study with four groups: vertically (v-HIV), horizontally infected (h-HIV) individuals, and two control groups. An MMR booster was offered to seronegative individuals. RESULTS: Measles seropositivity and IgG antibodies were significantly lower in v-HIV than in the other groups...
January 1, 2024: AIDS
https://read.qxmd.com/read/38061021/predicting-tuberculosis-at-antiretroviral-therapy-initiation-the-combination-of-monocyte-to-lymphocyte-ratio-and-hemoglobin-level-may-be-a-key
#122
JOURNAL ARTICLE
Tetsuo Tsukamoto, Dean L Winslow
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/38061020/aids-changes-in-leadership
#123
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/38016159/ending-the-hiv-epidemic-in-the-united-states-lessons-from-eswatini
#124
JOURNAL ARTICLE
Jessica Justman, Connor Wright, Wafaa M El-Sadr
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/37962215/short-term-weight-gain-after-antiretroviral-therapy-initiation-may-have-long-term-consequences
#125
JOURNAL ARTICLE
Iulia Filip
No abstract text is available yet for this article.
January 1, 2024: AIDS
https://read.qxmd.com/read/37939141/a-study-of-the-pharmacokinetics-safety-and-efficacy-of-bictegravir-emtricitabine-tenofovir-alafenamide-in-virologically-suppressed-pregnant-women-with-hiv
#126
MULTICENTER STUDY
Haeyoung Zhang, Jason T Hindman, Ludwig Lin, Maggie Davis, Justin Shang, Deqing Xiao, Anchalee Avihingsanon, Priyanka Arora, Ramesh Palaparthy, Sandhya Girish, Dhananjay D Marathe
OBJECTIVE: The objective of this study was to assess the pharmacokinetics, safety, and efficacy and confirm the dose of once-daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF; B/F/TAF) during pregnancy. DESIGN: An open-label, multicenter, single-arm, phase 1b study (NCT03960645) was conducted in 33 virologically suppressed pregnant women with HIV-1. METHODS: Participants received B/F/TAF (50/200/25 mg) from the second or third trimester through ∼16 weeks postpartum...
January 1, 2024: AIDS
https://read.qxmd.com/read/37788108/impact-of-a-livelihood-intervention-on-gender-roles-and-relationship-power-among-people-with-hiv
#127
RANDOMIZED CONTROLLED TRIAL
Lila A Sheira, Pauline Wekesa, Craig R Cohen, Elly Weke, Edward A Frongillo, A Rain Mocello, Shari L Dworkin, Rachel L Burger, Sheri D Weiser, Elizabeth A Bukusi
OBJECTIVE: To evaluate the impact of an agricultural livelihood intervention on gender role conflict and sexual relationship power among people with HIV (PWH) in western Kenya. DESIGN: Study participants were enrolled in Shamba Maisha , a cluster randomized controlled trial of an agricultural intervention conducted among PWH across 16 health facilities during 2016-2020. Intervention participants received a water pump, seeds, and agricultural and financial training; control participants received standard of HIV care...
January 1, 2024: AIDS
https://read.qxmd.com/read/38170505/the-association-of-changes-in-depression-severity-after-the-onset-of-the-covid-19-pandemic-and-viral-non-suppression-among-people-with-hiv
#128
JOURNAL ARTICLE
Tarfa Verinumbe, Catherine R Lesko, Richard D Moore, Anthony T Fojo, Jeanne Keruly, LaQuita N Snow, Heidi Hutton, Geetanjali Chander, Jarratt D Pytell, Oluwaseun Falade-Nwulia
OBJECTIVE: This study sought to characterize changes in depressive symptom severity during the COVID-19 pandemic and the association of these changes with HIV viral nonsuppression among people with HIV (PWH). DESIGN: A clinical cohort study. METHODS: We included PWH in the Johns Hopkins HIV Clinical Cohort who completed the Patient Health Questionnaire 8 (PHQ-8) prepandemic (1 March 2018 to 28 February 2020) and during the COVID-era (1 September 2020 to 28 February 2022)...
December 29, 2023: AIDS
https://read.qxmd.com/read/38170470/enabling-effective-differentiated-service-delivery-transitions-for-people-on-antiretroviral-treatment
#129
JOURNAL ARTICLE
Lynne Wilkinson, Anna Grimsrud
No abstract text is available yet for this article.
December 27, 2023: AIDS
https://read.qxmd.com/read/38133656/prep-availability-among-health-facilities-participating-in-the-global-iedea-consortium
#130
JOURNAL ARTICLE
Samuel Kebede, Ellen Brazier, Aimee M Freeman, Timothy R Muwonge, Jun Yong Choi, Renee de Waal, Armel Poda, Carina Cesar, Athanase Munyaneza, Charles Kasozi, Mark Kristoffer U Pasayan, Keri N Althoff, Alisho Shongo, Nicola Low, Didier Ekouevi, Valdiléa G Veloso, Jonathan Ross
BACKGROUND: While recognized as a key HIV prevention strategy, preexposure prophylaxis (PrEP) availability and accessibility are not well documented globally. We aimed to describe PrEP drug registration status and the availability of PrEP services across HIV care sites participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium. METHODS: We used country-level PrEP drug registration status from the AIDS Vaccine Advocacy Coalition and data from IeDEA surveys conducted in 2014, 2017 and 2020 among participating HIV clinics in seven global regions...
December 22, 2023: AIDS
https://read.qxmd.com/read/38133660/rapid-antiretroviral-therapy-in-primary-hiv-1-infection-enhances-immune-recovery
#131
JOURNAL ARTICLE
John Patrick Thornhill, Julie Fox, Genevieve Elizabeth Martin, Rebecca Hall, Julianne Lwanga, Heather Lewis, Helen Brown, Nicola Robinson, Kristen Kuldanek, Sabine Kinloch, Nneka Nwokolo, Gary Whitlock, Sarah Fidler, John Frater
OBJECTIVE: :We present findings from a large cohort of individuals treated during Primary HIV Infection (PHI) and examine the impact of time from HIV-1 acquisition to antiretroviral therapy (ART) initiation on clinical outcomes. We also examine the temporal changes in the demographics of individuals presenting with PHI to inform HIV-1 prevention strategies. METHODS: :Individuals who fulfilled the criteria of PHI and started ART within three months of confirmed HIV-1 diagnosis were enrolled between 2009 and 2020...
December 21, 2023: AIDS
https://read.qxmd.com/read/38126350/life-course-history-of-physical-and-sexual-abuse-is-associated-with-cardiovascular-disease-risk-among-women-living-with-and-without-hiv
#132
JOURNAL ARTICLE
Allison A Appleton, Mark H Kuniholm, Elizabeth Vásquez, Mardge H Cohen, Jessica Donohue, Michelle Floris-Moore, M Reuel Friedman, David B Hanna, Matthew J Mimiaga, Caitlin A Moran, Michael W Plankey, Linda A Teplin, Sanyog G Shitole, Deanna Ware, Deborah L Jones, Jenni Wise
OBJECTIVE: Sexual and physical abuse predict cardiovascular disease (CVD) among women in the general population. Women living with HIV (WLWH) report more abuse and have higher CVD risk compared to other women, yet associations between abuse history and CVD have not been considered among WLWH. This study fills this gap, and describes possible pathways linking abuse to CVD risk among WLWH and women living without HIV (WLWOH). METHODS: Using 25 years of data from the Women's Interagency HIV Study (n = 2734; WLWH n = 1963; WLWOH n = 771), we used longitudinal generalized estimating equations to test associations between sexual (SA) and physical abuse (PA) with CVD risk...
December 21, 2023: AIDS
https://read.qxmd.com/read/38126363/assessing-transmission-attribution-risk-from-simulated-sequencing-data-in-hiv-molecular-epidemiology
#133
JOURNAL ARTICLE
Fabrícia F Nascimento, Sanjay R Mehta, Susan J Little, Erik M Volz
BACKGROUND: HIV molecular epidemiology (ME) is the analysis of sequence data together with individual-level clinical, demographic, and behavioral data to understand HIV epidemiology. The use of ME has raised concerns regarding identification of the putative source in direct transmission events. This could result in harm ranging from stigma to criminal prosecution in some jurisdictions. Here we assessed the risks of ME using simulated HIV genetic sequencing data. METHODS: We simulated social networks of men-who-have-sex-with-men, calibrating the simulations to data from San Diego...
December 19, 2023: AIDS
https://read.qxmd.com/read/38126342/urine-tenofovir-and-dried-blood-spot-tenofovir-diphosphate-concentrations-and-viraemia-in-people-taking-efavirenz-and-dolutegravir-based-antiretroviral-therapy
#134
JOURNAL ARTICLE
Jienchi Dorward, Katya Govender, Pravikrishnen Moodley, Richard Lessells, Natasha Samsunder, Yukteshwar Sookrajh, Thomas R Fanshawe, Philip J Turner, Christopher C Butler, Paul K Drain, Gail N Hayward, Nigel Garrett
OBJECTIVE: We aimed to determine whether urine tenofovir (TFV) and dried blood spot (DBS) tenofovir diphosphate (TFV-DP) concentrations are associated with concurrent HIV viraemia. DESIGN: Cross-sectional study among people with HIV (PWH) receiving tenofovir disoproxil fumarate (TDF)-based antiretroviral therapy (ART). METHODS: We used dual tandem liquid chromatography and mass spectrometry to measure urine TFV and DBS TFV-DP concentrations, and evaluated their associations with concurrent viraemia ≥1000 copies/mL using logistic regression models...
December 19, 2023: AIDS
https://read.qxmd.com/read/38100633/quantifying-the-association-of-individual-level-characteristics-with-disparities-in-kidney-transplant-waitlist-addition-among-people-with-hiv
#135
JOURNAL ARTICLE
Brittany A Shelton, Bisakha Sen, David J Becker, Paul A MacLennan, Henna Budhwani, Jayme E Locke
BACKGROUND: Over 45% of people with HIV (PWH) in the United States ≥50 years old and are at heightened risk of aging-related comorbidities including end-stage kidney disease (ESKD), for which kidney transplant is the optimal treatment. Among ESKD patients, PWH have lower likelihood of waitlisting, a requisite step in the transplant process, than individuals without HIV. It is unknown what proportion of the inequity by HIV-status can be explained by demographics, medical characteristics, substance use history, and geography...
December 14, 2023: AIDS
https://read.qxmd.com/read/38092012/the-relationship-between-alcohol-consumption-and-risk-of-hiv-in-married-men-a-multi-country-study-on-sub-saharan-africa
#136
JOURNAL ARTICLE
Lukas König, Petal Petersen Williams, Paul A Shuper, Charlotte Probst
OBJECTIVE: A key factor for incidence of HIV is alcohol consumption. It impacts judgment and the probability to overlook risk-relevant information, which creates a pathway to reduced adherence to biomedical prevention and engagement in condomless sex. We strengthen the understanding of the link between alcohol consumption and risk of HIV among married men in Sub-Saharan Africa (SSA), as we use comprehensive population-level data to provide robust evidence with high external validity. DESIGN: Cross-sectional data analysis...
December 13, 2023: AIDS
https://read.qxmd.com/read/38079581/cerebrospinal-fluid-cxcl13-concentration-for-diagnosis-and-monitoring-of-neurosyphilis-in-people-living-with-hiv-a-prostective-cohort-study
#137
JOURNAL ARTICLE
Ricardo de S Carvalho, Isabelle de C Rangel, Michel M Soane, Natália B B Saraiva, Victor Herbst, Fernando R A Ferry
OBJECTIVES: The study aimed to assess and compare CSF-CXCL13 levels in People Living with HIV (PLWH) with suspected neurosyphilis (NS), those with syphilis but without NS, and patients without treponema infection. Additionally, it aimed to evaluate changes in CSF-CXCL13 concentrations before and after antibiotic treatment. DESIGN: This was a prospective cohort study involving 93 PLWH suspected of NS. All participants underwent lumbar puncture, with CSF-CXCL13 levels measured at baseline and during follow-up in patients diagnosed with NS...
December 12, 2023: AIDS
https://read.qxmd.com/read/38079588/heavy-arv-exposure-and-exhausted-limited-arv-options-predictors-and-clinical-outcomes
#138
JOURNAL ARTICLE
Amanda Mocroft, Annegret Pelchen-Matthews, Jennifer Hoy, Josep M Llibre, Bastian Neesgaard, Nadine Jaschinski, Pere Domingo, Line Dahlerup Rasmussen, Huldrych F Günthard, Bernard Surial, Angela Öllinger, Michael Knappik, Stephan De Wit, Ferdinand Wit, Cristina Mussini, Joerg Vehreschild, Antonella D'Arminio Monforte, Anders Sonnerborg, Antonella Castagna, Alain Volny Anne, Vani Vannappagari, Cal Cohen, Wayne Greaves, Jan C Wasmuth, Vincenzo Spagnuolo, Lene Ryom
OBJECTIVES: People with HIV and extensive antiretroviral exposure may have limited/exhausted treatment options (LExTO) due to resistance, comorbidities, or antiretroviral-related toxicity. Predictors of LExTO were investigated in the RESPOND cohort. METHODS: Participants on ART for at least 5 years were defined as having LExTO when switched to at least two anchor agents and one-third antiretroviral (any class), a two-drug regimen of two anchor agents (excluding rilpivirine with dolutegravir/cabotegravir), or at least three nucleoside reverse transcriptase inhibitors...
December 11, 2023: AIDS
https://read.qxmd.com/read/38061029/dysbiosis-of-gut-microbiota-and-metabolites-during-aids-implications-for-cd4-t-cell-reduction-and-immune-activation
#139
JOURNAL ARTICLE
Jie Zhou, Yuecong Yang, Zhiman Xie, Dongjia Lu, Jinping Huang, Liuyang Lan, Baodong Guo, Xiping Yang, Qing Wang, Zhuoxin Li, Yu Zhang, Xing Yang, Sufang Ai, Ningmei Liu, Hao Liang, Li Ye, Jiegang Huang
OBJECTIVE: Identifying the gut microbiota associated with host immunity in the AIDS stage. DESIGN: We performed a cross-sectional study. METHODS: We recruited people living with HIV (PLWH) in the AIDS or non-AIDS stage and evaluated their gut microbiota and metabolites by using 16S ribosomal RNA (rRNA) sequencing and liquid chromatography-mass spectrometry (LC-MS). Machine learning (ML) models were used to analyze the correlations between key bacteria and CD4+ T cell count, CD4+ T cell activation, bacterial translocation, gut metabolites, and KEGG functional pathways...
December 7, 2023: AIDS
https://read.qxmd.com/read/38051790/the-association-between-anticholinergic-sedative-burden-and-physical-frailty-in-people-aging-with-hiv
#140
JOURNAL ARTICLE
Henry Ukachukwu Michael, Marie-Josée Brouillette, Robyn Tamblyn, Lesley K Fellows, Nancy E Mayo
OBJECTIVE: This study aimed to estimate the strength of the association between anticholinergic/sedative burden and concurrent physical frailty in people aging with HIV. DESIGN: This cross-sectional analysis examined baseline data from 824 adults with a mean age of 53 enrolled in the Positive Brain Health Now study. METHODS: Anticholinergic medications were identified using four methods: Anticholinergic Cognitive Burden (ACB) scale, Anticholinergic Risk Scale (ARS), Anticholinergic Drug Scale (ADS), and the anticholinergic list of the Anticholinergic and Sedative Burden Catalog (ACSBC)...
December 4, 2023: AIDS
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