journal
https://read.qxmd.com/read/38170505/the-association-of-changes-in-depression-severity-after-the-onset-of-the-covid-19-pandemic-and-viral-non-suppression-among-people-with-hiv
#101
JOURNAL ARTICLE
Tarfa Verinumbe, Catherine R Lesko, Richard D Moore, Anthony T Fojo, Jeanne Keruly, LaQuita N Snow, Heidi Hutton, Geetanjali Chander, Jarratt D Pytell, Oluwaseun Falade-Nwulia
OBJECTIVE: This study sought to characterize changes in depressive symptom severity during the COVID-19 pandemic and the association of these changes with HIV viral nonsuppression among people with HIV (PWH). DESIGN: A clinical cohort study. METHODS: We included PWH in the Johns Hopkins HIV Clinical Cohort who completed the Patient Health Questionnaire 8 (PHQ-8) prepandemic (1 March 2018 to 28 February 2020) and during the COVID-era (1 September 2020 to 28 February 2022)...
December 29, 2023: AIDS
https://read.qxmd.com/read/38170470/enabling-effective-differentiated-service-delivery-transitions-for-people-on-antiretroviral-treatment
#102
JOURNAL ARTICLE
Lynne Wilkinson, Anna Grimsrud
No abstract text is available yet for this article.
December 27, 2023: AIDS
https://read.qxmd.com/read/38133656/prep-availability-among-health-facilities-participating-in-the-global-iedea-consortium
#103
JOURNAL ARTICLE
Samuel Kebede, Ellen Brazier, Aimee M Freeman, Timothy R Muwonge, Jun Yong Choi, Renee de Waal, Armel Poda, Carina Cesar, Athanase Munyaneza, Charles Kasozi, Mark Kristoffer U Pasayan, Keri N Althoff, Alisho Shongo, Nicola Low, Didier Ekouevi, Valdiléa G Veloso, Jonathan Ross
BACKGROUND: While recognized as a key HIV prevention strategy, preexposure prophylaxis (PrEP) availability and accessibility are not well documented globally. We aimed to describe PrEP drug registration status and the availability of PrEP services across HIV care sites participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium. METHODS: We used country-level PrEP drug registration status from the AIDS Vaccine Advocacy Coalition and data from IeDEA surveys conducted in 2014, 2017 and 2020 among participating HIV clinics in seven global regions...
December 22, 2023: AIDS
https://read.qxmd.com/read/38133660/rapid-antiretroviral-therapy-in-primary-hiv-1-infection-enhances-immune-recovery
#104
JOURNAL ARTICLE
John Patrick Thornhill, Julie Fox, Genevieve Elizabeth Martin, Rebecca Hall, Julianne Lwanga, Heather Lewis, Helen Brown, Nicola Robinson, Kristen Kuldanek, Sabine Kinloch, Nneka Nwokolo, Gary Whitlock, Sarah Fidler, John Frater
OBJECTIVE: :We present findings from a large cohort of individuals treated during Primary HIV Infection (PHI) and examine the impact of time from HIV-1 acquisition to antiretroviral therapy (ART) initiation on clinical outcomes. We also examine the temporal changes in the demographics of individuals presenting with PHI to inform HIV-1 prevention strategies. METHODS: :Individuals who fulfilled the criteria of PHI and started ART within three months of confirmed HIV-1 diagnosis were enrolled between 2009 and 2020...
December 21, 2023: AIDS
https://read.qxmd.com/read/38126353/optimizing-behavioral-and-pharmacological-smoking-cessation-interventions-among-people-with-hiv-results-of-a-factorial-design-randomized-trial
#105
JOURNAL ARTICLE
Seth Himelhoch, Deana Kelly, Chris deFilippi, Gregory Taylor, Melanie Bennett, Deborah Medoff, Lan Li, Robert Christiansen, Wendy Potts, Jonathan Shuter
BACKGROUND: People living with HIV/AIDS (PWH) smoke at nearly three times the rate of the general population. Interventions to promote sustained quitting among PWH are urgently needed. METHODS: Our study used a randomized factorial design to evaluate the effects of varenicline, compared to placebo, and behavioral cessation therapy, Positively Smoke Free (PSF), compared to Standard of Care (SOC) among PWH who smoke. The study was designed with power to detect a small effect (Cohen's h of ...
December 21, 2023: AIDS
https://read.qxmd.com/read/38126350/life-course-history-of-physical-and-sexual-abuse-is-associated-with-cardiovascular-disease-risk-among-women-living-with-and-without-hiv
#106
JOURNAL ARTICLE
Allison A Appleton, Mark H Kuniholm, Elizabeth Vásquez, Mardge H Cohen, Jessica Donohue, Michelle Floris-Moore, M Reuel Friedman, David B Hanna, Matthew J Mimiaga, Caitlin A Moran, Michael W Plankey, Linda A Teplin, Sanyog G Shitole, Deanna Ware, Deborah L Jones, Jenni Wise
OBJECTIVE: Sexual and physical abuse predict cardiovascular disease (CVD) among women in the general population. Women living with HIV (WLWH) report more abuse and have higher CVD risk compared to other women, yet associations between abuse history and CVD have not been considered among WLWH. This study fills this gap, and describes possible pathways linking abuse to CVD risk among WLWH and women living without HIV (WLWOH). METHODS: Using 25 years of data from the Women's Interagency HIV Study (n = 2734; WLWH n = 1963; WLWOH n = 771), we used longitudinal generalized estimating equations to test associations between sexual (SA) and physical abuse (PA) with CVD risk...
December 21, 2023: AIDS
https://read.qxmd.com/read/38126363/assessing-transmission-attribution-risk-from-simulated-sequencing-data-in-hiv-molecular-epidemiology
#107
JOURNAL ARTICLE
Fabrícia F Nascimento, Sanjay R Mehta, Susan J Little, Erik M Volz
BACKGROUND: HIV molecular epidemiology (ME) is the analysis of sequence data together with individual-level clinical, demographic, and behavioral data to understand HIV epidemiology. The use of ME has raised concerns regarding identification of the putative source in direct transmission events. This could result in harm ranging from stigma to criminal prosecution in some jurisdictions. Here we assessed the risks of ME using simulated HIV genetic sequencing data. METHODS: We simulated social networks of men-who-have-sex-with-men, calibrating the simulations to data from San Diego...
December 19, 2023: AIDS
https://read.qxmd.com/read/38126342/urine-tenofovir-and-dried-blood-spot-tenofovir-diphosphate-concentrations-and-viraemia-in-people-taking-efavirenz-and-dolutegravir-based-antiretroviral-therapy
#108
JOURNAL ARTICLE
Jienchi Dorward, Katya Govender, Pravikrishnen Moodley, Richard Lessells, Natasha Samsunder, Yukteshwar Sookrajh, Thomas R Fanshawe, Philip J Turner, Christopher C Butler, Paul K Drain, Gail N Hayward, Nigel Garrett
OBJECTIVE: We aimed to determine whether urine tenofovir (TFV) and dried blood spot (DBS) tenofovir diphosphate (TFV-DP) concentrations are associated with concurrent HIV viraemia. DESIGN: Cross-sectional study among people with HIV (PWH) receiving tenofovir disoproxil fumarate (TDF)-based antiretroviral therapy (ART). METHODS: We used dual tandem liquid chromatography and mass spectrometry to measure urine TFV and DBS TFV-DP concentrations, and evaluated their associations with concurrent viraemia ≥1000 copies/mL using logistic regression models...
December 19, 2023: AIDS
https://read.qxmd.com/read/38100633/quantifying-the-association-of-individual-level-characteristics-with-disparities-in-kidney-transplant-waitlist-addition-among-people-with-hiv
#109
JOURNAL ARTICLE
Brittany A Shelton, Bisakha Sen, David J Becker, Paul A MacLennan, Henna Budhwani, Jayme E Locke
BACKGROUND: Over 45% of people with HIV (PWH) in the United States ≥50 years old and are at heightened risk of aging-related comorbidities including end-stage kidney disease (ESKD), for which kidney transplant is the optimal treatment. Among ESKD patients, PWH have lower likelihood of waitlisting, a requisite step in the transplant process, than individuals without HIV. It is unknown what proportion of the inequity by HIV-status can be explained by demographics, medical characteristics, substance use history, and geography...
December 14, 2023: AIDS
https://read.qxmd.com/read/38092012/the-relationship-between-alcohol-consumption-and-risk-of-hiv-in-married-men-a-multi-country-study-on-sub-saharan-africa
#110
JOURNAL ARTICLE
Lukas König, Petal Petersen Williams, Paul A Shuper, Charlotte Probst
OBJECTIVE: A key factor for incidence of HIV is alcohol consumption. It impacts judgment and the probability to overlook risk-relevant information, which creates a pathway to reduced adherence to biomedical prevention and engagement in condomless sex. We strengthen the understanding of the link between alcohol consumption and risk of HIV among married men in Sub-Saharan Africa (SSA), as we use comprehensive population-level data to provide robust evidence with high external validity. DESIGN: Cross-sectional data analysis...
December 13, 2023: AIDS
https://read.qxmd.com/read/38079581/cerebrospinal-fluid-cxcl13-concentration-for-diagnosis-and-monitoring-of-neurosyphilis-in-people-living-with-hiv-a-prostective-cohort-study
#111
JOURNAL ARTICLE
Ricardo de S Carvalho, Isabelle de C Rangel, Michel M Soane, Natália B B Saraiva, Victor Herbst, Fernando R A Ferry
OBJECTIVES: The study aimed to assess and compare CSF-CXCL13 levels in People Living with HIV (PLWH) with suspected neurosyphilis (NS), those with syphilis but without NS, and patients without treponema infection. Additionally, it aimed to evaluate changes in CSF-CXCL13 concentrations before and after antibiotic treatment. DESIGN: This was a prospective cohort study involving 93 PLWH suspected of NS. All participants underwent lumbar puncture, with CSF-CXCL13 levels measured at baseline and during follow-up in patients diagnosed with NS...
December 12, 2023: AIDS
https://read.qxmd.com/read/38079588/heavy-arv-exposure-and-exhausted-limited-arv-options-predictors-and-clinical-outcomes
#112
JOURNAL ARTICLE
Amanda Mocroft, Annegret Pelchen-Matthews, Jennifer Hoy, Josep M Llibre, Bastian Neesgaard, Nadine Jaschinski, Pere Domingo, Line Dahlerup Rasmussen, Huldrych F Günthard, Bernard Surial, Angela Öllinger, Michael Knappik, Stephan De Wit, Ferdinand Wit, Cristina Mussini, Joerg Vehreschild, Antonella D'Arminio Monforte, Anders Sonnerborg, Antonella Castagna, Alain Volny Anne, Vani Vannappagari, Cal Cohen, Wayne Greaves, Jan C Wasmuth, Vincenzo Spagnuolo, Lene Ryom
OBJECTIVES: People with HIV and extensive antiretroviral exposure may have limited/exhausted treatment options (LExTO) due to resistance, comorbidities, or antiretroviral-related toxicity. Predictors of LExTO were investigated in the RESPOND cohort. METHODS: Participants on ART for at least 5 years were defined as having LExTO when switched to at least two anchor agents and one-third antiretroviral (any class), a two-drug regimen of two anchor agents (excluding rilpivirine with dolutegravir/cabotegravir), or at least three nucleoside reverse transcriptase inhibitors...
December 11, 2023: AIDS
https://read.qxmd.com/read/38061029/dysbiosis-of-gut-microbiota-and-metabolites-during-aids-implications-for-cd4-t-cell-reduction-and-immune-activation
#113
JOURNAL ARTICLE
Jie Zhou, Yuecong Yang, Zhiman Xie, Dongjia Lu, Jinping Huang, Liuyang Lan, Baodong Guo, Xiping Yang, Qing Wang, Zhuoxin Li, Yu Zhang, Xing Yang, Sufang Ai, Ningmei Liu, Hao Liang, Li Ye, Jiegang Huang
OBJECTIVE: Identifying the gut microbiota associated with host immunity in the AIDS stage. DESIGN: We performed a cross-sectional study. METHODS: We recruited people living with HIV (PLWH) in the AIDS or non-AIDS stage and evaluated their gut microbiota and metabolites by using 16S ribosomal RNA (rRNA) sequencing and liquid chromatography-mass spectrometry (LC-MS). Machine learning (ML) models were used to analyze the correlations between key bacteria and CD4+ T cell count, CD4+ T cell activation, bacterial translocation, gut metabolites, and KEGG functional pathways...
December 7, 2023: AIDS
https://read.qxmd.com/read/38051790/the-association-between-anticholinergic-sedative-burden-and-physical-frailty-in-people-aging-with-hiv
#114
JOURNAL ARTICLE
Henry Ukachukwu Michael, Marie-Josée Brouillette, Robyn Tamblyn, Lesley K Fellows, Nancy E Mayo
OBJECTIVE: This study aimed to estimate the strength of the association between anticholinergic/sedative burden and concurrent physical frailty in people aging with HIV. DESIGN: This cross-sectional analysis examined baseline data from 824 adults with a mean age of 53 enrolled in the Positive Brain Health Now study. METHODS: Anticholinergic medications were identified using four methods: Anticholinergic Cognitive Burden (ACB) scale, Anticholinergic Risk Scale (ARS), Anticholinergic Drug Scale (ADS), and the anticholinergic list of the Anticholinergic and Sedative Burden Catalog (ACSBC)...
December 4, 2023: AIDS
https://read.qxmd.com/read/38051788/the-immunogenicity-of-an-hiv-1-gag-conserved-element-dna-vaccine-in-people-with-hiv-and-receiving-antiretroviral-therapy
#115
JOURNAL ARTICLE
Jeffrey M Jacobson, Barbara K Felber, Huichao Chen, George N Pavlakis, James I Mullins, Stephen C de Rosa, Daniel R Kuritzkes, Georgia D Tomaras, Jennifer Kinslow, Yajing Bao, Maxine Olefsky, Margherita Rosati, Jenifer Bear, Drew Hannaman, Gregory M Laird, Joshua C Cyktor, Sonya L Heath, Ann C Collier, Susan L Koletar, Babafemi O Taiwo, Pablo Tebas, David A Wohl, Pablo F Belanzauran-Zamudio, M Juliana Mcelrath, Alan L Landay
OBJECTIVE: The primary objective of the study was to assess the immunogenicity of an HIV-1 Gag conserved element DNA vaccine (p24CE DNA) in people with HIV (PWH) receiving suppressive antiretroviral therapy (ART). DESIGN: AIDS Clinical Trials Group A5369 was a phase I/IIa, randomized, double-blind, placebo-controlled study of PWH receiving ART with plasma HIV-1 RNA less than 50 copies/ml, current CD4+ T-cell counts greater than 500 cells/μl, and nadir CD4+ T-cell counts greater than 350 cells/μl...
December 4, 2023: AIDS
https://read.qxmd.com/read/38051787/the-clinical-utility-of-three-frailty-measures-in-identifying-hiv-associated-neurocognitive-disorders
#116
JOURNAL ARTICLE
David J Moore, Ni Sun-Suslow, Ariadne A Nichol, Emily W Paolillo, Rowan Saloner, Scott L Letendre, Jennifer Iudicello, Erin E Morgan
OBJECTIVE: Frailty measures vary widely and the optimal measure for predicting HIV-associated neurocognitive disorders (HAND) is unclear. DESIGN: A study was conducted to examine the clinical utility of three widely used frailty measures in identifying HIV-associated neurocognitive disorders. METHODS: The study involved 284 people with HIV (PWH) at least 50 years enrolled at UC San Diego's HIV Neurobehavioral Research Program. Frailty measurements included the Fried Phenotype, the Rockwood Frailty Index, and the Veterans Aging Cohort Study (VACS) Index...
December 4, 2023: AIDS
https://read.qxmd.com/read/38051784/moving-beyond-the-guidelines-to-improve-detection-of-viral-hepatitis-and-linkage-to-care
#117
JOURNAL ARTICLE
Iulia Filip
No abstract text is available yet for this article.
December 4, 2023: AIDS
https://read.qxmd.com/read/37965742/who-is-championing-programming-to-ensure-children-who-are-hiv-exposed-yet-uninfected-thrive-to-their-fullest-potential
#118
JOURNAL ARTICLE
Kathleen M Powis, Giulia Moschen, Jessica Jexler, Agnes Ronan
No abstract text is available yet for this article.
December 1, 2023: AIDS
https://read.qxmd.com/read/37965741/false-positive-hiv-screening-tests-during-the-covid-19-pandemic-a-passing-trend
#119
JOURNAL ARTICLE
Rinat Lasmanovich, Dor Atias, Orna Mor, Uri Obolski
False-positive fourth-generation HIV screening tests are rare and are usually associated with various infections and autoimmune diseases. SARS-CoV-2 infection and vaccination were recently linked with false-positive HIV screening test results. However, little is known about false-positives in people who performed HIV screening tests after outbreaks of different SARS-CoV-2 strains and vaccination campaigns. Here, we examined the false-positive rates in samples collected by the Israeli AIDS Task Force in 2018--2022, with respect to such factors...
December 1, 2023: AIDS
https://read.qxmd.com/read/37965740/sexually-transmitted-infections-in-people-with-multidrug-resistant-hiv
#120
JOURNAL ARTICLE
Tommaso Clemente, Riccardo Lolatto, Rebecka Papaioannu Borjesson, Massimiliano Fabbiani, Elio Manzillo, Elisa Fronti, Simona Di Giambenedetto, Roberta Gagliardini, Stefano Rusconi, Maria M Santoro, Antonella Castagna, Vincenzo Spagnuolo
Retrospective, cohort analysis including people with four-class drug-resistant HIV. Bacterial sexually transmitted infections (STIs) had an incidence of 1.3/100-person-years-of-follow-up (PYFU) in men (3.5/100-PYFU in MSM) whereas no STIs were diagnosed in women. The occurrence of STIs in this fragile population might be related to the achievement of good HIV infection control; however, given the remaining risk of virological failure and possible transmission of a multidrug-resistant virus, STI prevention counselling and HIV viremia monitoring should be prioritized...
December 1, 2023: AIDS
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