journal
https://read.qxmd.com/read/38016165/ambient-particulate-matter-and-renal-function-decline-in-hiv-aids-patients-exploring-the-mediating-role-of-tyg-index
#81
JOURNAL ARTICLE
Hongfei Ma, Wei Liang, Aojing Han, Qian Zhang, Shun Gong, Yang Bai, Daiming Gao, Hao Xiang, Xia Wang
OBJECTIVE: We aimed to explore the effect of particulate matter (PM) exposure on renal function in people living with HIV/AIDS (PWHA). METHODS: A total of 37,739 repeated measurements were conducted on eGFR levels, serum creatinine (Scr), and the triglyceride-glucose (TyG) index in 6,958 PWHAs. The relationship between 1-28 day moving averages of PM concentrations with Scr and eGFR was assessed using linear mixed-effects models. Modified Poisson regression models were employed to assess the associations of cumulative PM exposure with the incidence of chronic kidney disease (CKD)...
November 28, 2023: AIDS
https://read.qxmd.com/read/38016163/primary-hiv-infection-features-colonic-damage-and-neutrophil-inflammation-yet-containment-of-microbial-translocation
#82
JOURNAL ARTICLE
Camilla Tincati, Valeria Bono, Elvira Stefania Cannizzo, Delfina Tosi, Federica Savi, Camilla Falcinella, Anna Casabianca, Chiara Orlandi, Carmelo Luigiano, Matteo Augello, Stefano Rusconi, Antonio Muscatello, Alessandra Bandera, Andrea Calcagno, Andrea Gori, Silvia Nozza, Giulia Marchetti
INTRODUCTION: Impairment of the gastrointestinal (GI) barrier leads to microbial translocation and peripheral immune activation which are linked to disease progression. Data in the setting of primary HIV/SIV infection suggest that gut barrier damage is one of the first events of the pathogenic cascade, preceding mucosal immune dysfunction and microbial translocation. We assessed gut structure and immunity as well as microbial translocation in acutely- and chronically-infected, combination cART-naïve individuals...
November 28, 2023: AIDS
https://read.qxmd.com/read/38016160/effect-of-tb-hiv-co-treatment-on-clinical-and-growth-outcomes-among-hospitalized-children-newly-initiating-antiretroviral-therapy
#83
JOURNAL ARTICLE
Ashenafi S Cherkos, Lisa M Cranmer, Irene Njuguna, Sylvia M LaCourse, Cyrus Mugo, Hellen Moraa, Elizabeth Maleche-Obimbo, Daniel A Enquobahrie, Barbra A Richardson, Dalton Wamalwa, Grace John-Stewart
OBJECTIVE: Evaluate effects of TB-HIV co-treatment on clinical and growth outcomes in children with HIV (CHIV). DESIGN: Longitudinal study among Kenyan hospitalized ART-naive CHIV in the PUSH trial (NCT02063880). METHODS: CHIV started ART within 2 weeks of enrollment; Anti-TB therapy was initiated based on clinical and TB diagnostics. Children were followed for 6 months with serial viral load, CD4%, and growth assessments (weight-for-age [WAZ], height-for-age [HAZ], and weight-for-height [WHZ])...
November 28, 2023: AIDS
https://read.qxmd.com/read/37991523/perinatal-hiv-infection-is-associated-with-deficits-in-muscle-function-in-children-and-adolescents-a-cross-sectional-study-in-zimbabwe
#84
JOURNAL ARTICLE
Celia L Gregson, Andrea M Rehman, Ruramayi Rukuni, Cynthia Mukwasi-Kahari, Tafadzwa Madanhire, Farirayi Kowo-Nyakoko, Mícheál Ó Breasail, Lisha Jeena, Grace Mchugh, Suzanne Filteau, Joseph Chipanga, Victoria Simms, Hilda Mujuru, Kate A Ward, Rashida A Ferrand
OBJECTIVES: :To determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether antiretroviral therapy (ART) regime is associated with muscle quality. DESIGN: :A cross-sectional study in Harare, Zimbabwe. METHODS: :The study recruited CWH aged 8-16years, taking ART for ≥2years, from HIV clinics, and HIV-uninfected children from local schools. Muscle outcomes comprised grip strength measured by hand-held Jamar dynamometer, lower-limb power measured by standing long-jump distance, lean mass measured by dual-energy X-ray absorptiometry, and muscle density (reflecting intramuscular fat) by peripheral quantitative computed tomography...
November 22, 2023: AIDS
https://read.qxmd.com/read/37991521/fetal-growth-assessed-via-ultrasound-in-relation-to-maternal-hiv-infection-status-and-antiretroviral-regimens
#85
JOURNAL ARTICLE
Paige L Williams, Brad Karalius, Kunjal Patel, Ann Aschengrau, Nahida Chakhtoura, Naomi Enriquez, Jack Moye, Patricia A Garvie, Dina Monte, George R Seage, Carmen Zorrilla, Marisa M Mussi-Pinhata
OBJECTIVE: :To evaluate effects of maternal HIV and antiretroviral treatment (ART) on intrauterine fetal growth. DESIGN: :Prospective cohort studies of HIV and ZIKA infection among women living with HIV (WLHIV) and women not living with HIV (WNLHIV) conducted in Brazil and the US from 2016-2020. METHODS: :We evaluated fetal growth via repeated ultrasounds and calculated Z-scores for fetal growth measures using Intergrowth-21st standards among women with singleton pregnancies...
November 22, 2023: AIDS
https://read.qxmd.com/read/37976053/weight-loss-associated-with-semaglutide-treatment-among-people-with-hiv
#86
JOURNAL ARTICLE
Lara Haidar, Heidi M Crane, Robin M Nance, Allison Webel, Stephanie A Ruderman, Bridget M Whitney, Amanda L Willig, Sonia Napravnik, L Sarah Mixson, Christine Leong, Alekhya Lavu, Laila Aboulatta, Mindy Dai, Andrew Hahn, Michael S Saag, Laura Bamford, Edward Cachay, Mari M Kitahata, Kenneth H Mayer, Jeffrey Jacobson, Richard D Moore, Joseph A C Delaney, Lydia N Drumright, Sherif Eltonsy
OBJECTIVE: There is limited real-world evidence about the effectiveness of semaglutide for weight loss among people with HIV (PWH). We aimed to investigate weight change in a US cohort of PWH who initiated semaglutide treatment. DESIGN: Observational study using the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort. METHODS: We identified adult PWH who initiated semaglutide between 2018 and 2022 and with at least two weight measurements...
November 17, 2023: AIDS
https://read.qxmd.com/read/37976073/ex-vivo-rectal-tissue-infection-with-hiv-1-to-assess-time-to-protection-following-oral-prep-with-tdf-ftc-a-sub-study-of-the-anrs-prevenir-study
#87
JOURNAL ARTICLE
Sylvain Chawki, Lauriane Goldwirt, Mayssam El Mouhebb, Audrey Gabassi, Milad Taouk, Iris Bichard, Bénédicte Loze, Ali Amara, Rhonda Brand, Aaron Siegel, Ian McGowan, Dominique Costagliola, Lambert Assoumou, Jean-Michel Molina, Constance Delaugerre
OBJECTIVES: We wished to assess time to protection from HIV-1 infection following oral tenofovir disoproxil and emtricitabine (TDF/FTC) as pre-exposure prophylaxis (PrEP), using ex vivo rectal tissue infections and drug concentration measures in blood and rectal tissue. DESIGN/METHODS: Participants from the ANRS PREVENIR study (NCT03113123) were offered this sub-study after a 14-day wash-out. We used an ex vivo model to evaluate rectal tissue HIV-1 susceptibility before and after PrEP, two hours after 2 pills or seven days of a daily pill of TDF/FTC...
November 16, 2023: AIDS
https://read.qxmd.com/read/37976040/geographic-variations-of-prep-reversal-and-abandonment-among-us-counties
#88
JOURNAL ARTICLE
Rahel Dawit, William C Goedel, Sean C Reid, Jalpa A Doshi, Amy S Nunn, Philip A Chan, Lorraine T Dean
OBJECTIVE: In the United States (US), 1 in 5 newly insurer-approved pre-exposure prophylaxis (PrEP) prescriptions are reversed with over 70% of those reversed, being abandoned. Given the Ending the HIV Epidemic (EHE) initiative's goals, we assessed geographic variations of PrEP reversal and abandonment across EHE and non-EHE counties in the US. DESIGN: This was a cross-sectional analysis of secondary data. METHODS: Data were collected from Symphony Analytics for adults ≥18 years old, with a newly prescribed PrEP claim...
November 16, 2023: AIDS
https://read.qxmd.com/read/37976039/clonal-hematopoiesis-of-indeterminate-potential-in-persons-living-with-hiv
#89
JOURNAL ARTICLE
Andreas D Knudsen, Christian Winther Eskelund, Thomas Benfield, Yanan Zhao, Marco Gelpi, Lars Køber, Marius Trøseid, Klaus F Kofoed, Sisse R Ostrowski, Cavan Reilly, Álvaro H Borges, Kirsten Grønbæk, Susanne D Nielsen
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with older age, inflammation and with risk of coronary artery disease (CAD). We aimed to characterize the burden of CHIP, and to explore the association between CHIP, inflammatory markers, and CAD in older persons living with HIV (PLWH). METHODS: From the Copenhagen Comorbidity in HIV Infection (COCOMO) study, we included 190 individuals older than 55 years of age. We defined CHIP as variant allele fraction ≥ 2%...
November 16, 2023: AIDS
https://read.qxmd.com/read/37877286/response-to-correspondence-to-no-long-term-effect-of-past-pneumocystis-jirovecii-pneumonia-on-pulmonary-function-in-people-with-hiv
#90
COMMENT
Patrick G A Oomen, Berend J van Welzen, Inez Bronsveld, Andy I M Hoepelman, Tania Mudrikova
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877285/response-to-no-long-term-effect-of-past-pneumocystis-jirovecii-pneumonia-on-pulmonary-function-in-people-with-hiv
#91
COMMENT
Katerina L Byanova, Laurence Huang
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877284/demographic-patterns-and-disparities-in-new-hiv-diagnoses-attributed-to-injection-drug-use-in-the-united-states
#92
JOURNAL ARTICLE
Joseph G Rosen, Javier Cepeda, Ju Nyeong Park
People who inject drugs (PWID) exhibit disproportionate HIV burdens in the United States. We characterized longitudinal patterns and demographic disparities in new HIV diagnoses attributed to injection drug use (IDU) in 2008-2020. Although new IDU-attributed HIV diagnoses fell by 53.9%, new HIV diagnoses remained disproportionately elevated in female (100.9/100 000), Black (258.8/100 000), and Hispanic (131.0/100 000) PWID. Despite considerable declines in new HIV diagnoses, disparities by race/ethnicity and sex persist among US PWID...
November 15, 2023: AIDS
https://read.qxmd.com/read/37877283/hepatic-steatosis-after-switching-to-integrase-inhibitor-based-regimens-does-not-parallel-short-term-weight-gain
#93
JOURNAL ARTICLE
Alejandro Gonzalez-Serna, Juan Macías, Pilar Rincon, Maria Jose Arriaza, Anais Corma-Gomez, Marta Santos, Marta Fernandez-Fuertes, Juan Antonio Pineda, Luis Miguel Real
We studied hepatic steatosis in people with HIV (PWH) who switched to an integrase inhibitor (INSTI)-based regimen. One hundred and fifty-four PWH were included. After 48 weeks, median (Q1-Q3) weight gain was 1.2 (-0.6 to 3.8) kg and median (Q1-Q3) controlled attenuation parameter (CAP) change was -4 (-33 to 27) dB/m. Weight gain was weakly correlated with CAP change [R2 95% confidence interval (CI) = 0.144 (-0.014 to 0.296); P = 0.074)]. Changes in hepatic steatosis after switching to INSTI-based regimens do not seem to parallel weight gain after 1 year...
November 15, 2023: AIDS
https://read.qxmd.com/read/37877282/simplified-regimens-for-aids-related-cryptococcal-meningitis-improving-its-access-in-africa
#94
JOURNAL ARTICLE
Vinie Kouamou, Azure Tariro Makadzange
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877281/addressing-atherosclerotic-cardiovascular-disease-risk-in-persons-with-hiv
#95
JOURNAL ARTICLE
Sepiso K Masenga, Ian J Woolley
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877280/frailty-and-cognition-in-older-people-with-hiv-recognizing-the-importance-of-geriatric-syndromes
#96
JOURNAL ARTICLE
Julian Falutz, Daniel Lee
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877279/metabolic-dysfunction-associated-steatotic-liver-disease-in-persons-with-hiv-understanding-the-serious-implications-and-renaming-of-fatty-liver-disease
#97
JOURNAL ARTICLE
https://read.qxmd.com/read/37877278/is-it-possible-to-get-a-two-for-one-can-we-slow-cognitive-decline-by-treating-vascular-disease-risk-factors
#98
JOURNAL ARTICLE
Shruti P Agnihotri, Edgar T Overton
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877277/-zombie-proviruses-in-the-spotlight-exploring-the-dark-side-of-hiv-persistence
#99
COMMENT
Alexander O Pasternak, Tetsuo Tsukamoto, Ben Berkhout
No abstract text is available yet for this article.
November 15, 2023: AIDS
https://read.qxmd.com/read/37877276/improvement-in-cd4-cell-count-among-people-with-hiv-in-new-york-city-2007-2021
#100
JOURNAL ARTICLE
Qiang Xia, Lorne Farovitch, Daniel Bertolino, Anthony Romano, Jamie Huang, Kavita Misra, Lucia V Torian
BACKGROUND: A higher CD4+ cell count among people with HIV (PWH) is associated with improved immune function and reduced HIV-related morbidity and mortality. The purpose of this analysis is to report the trend in CD4+ cell count among PWH in New York City (NYC). METHODS: We conducted a serial cross-sectional analysis using the NYC HIV registry data and reported the proportion of PWH with a CD4+ cell count of 500 cells/μl or above, overall and by sex, race or ethnicity, and age...
November 15, 2023: AIDS
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