Shoichi Kuramitsu, Masanobu Ohya, Tomohiro Shinozaki, Hiromasa Otake, Kazunori Horie, Hiroyoshi Kawamoto, Futoshi Yamanaka, Masahiro Natsuaki, Hiroki Shiomi, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura
Background The risk factors and long-term clinical outcomes of patients with definite stent thrombosis (ST) after second-generation drug-eluting stent (DES) implantation have not yet been adequately assessed. Methods and Results The REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation DES Implantation) included 313 definite ST of second-generation DES (early ST, n=179; late ST, n=66; very late ST, n=68). Four patients without definite ST of second-generation DES were identified as control patients for each ST case...
June 2019: Circulation. Cardiovascular Interventions
Fabrizio D'Ascenzo, Mario Bollati, Fabrizio Clementi, Davide Castagno, Bo Lagerqvist, Jose M de la Torre Hernandez, Juriën M ten Berg, Bruce R Brodie, Philip Urban, Lisette Okkels Jensen, Gabriel Sardi, Ron Waksman, John M Lasala, Stefanie Schulz, Gregg W Stone, Flavio Airoldi, Antonio Colombo, Gilles Lemesle, Robert J Applegate, Piergiovanni Buonamici, Ajay J Kirtane, Anetta Undas, Imad Sheiban, Fiorenzo Gaita, Giuseppe Sangiorgi, Maria Grazia Modena, Giacomo Frati, Giuseppe Biondi-Zoccai
BACKGROUND: Stent thrombosis remains among the most feared complications of percutaneous coronary intervention (PCI) with stenting. However, data on its incidence and predictors are sparse and conflicting. We thus aimed to perform a collaborative systematic review on incidence and predictors of stent thrombosis. METHODS: PubMed was systematically searched for eligible studies from the drug-eluting stent (DES) era (1/2002-12/2010). Studies were selected if including ≥ 2000 patients undergoing stenting or reporting on ≥ 25 thromboses...
July 31, 2013: International Journal of Cardiology
Sorin J Brener, Ecaterina Cristea, Ajay J Kirtane, Margaret B McEntegart, Ke Xu, Roxana Mehran, Gregg W Stone
OBJECTIVES: The aim of this study was to examine the incidence, correlates, and consequences of intra-procedural stent thrombosis (IPST) in patients with acute coronary syndromes (ACS). BACKGROUND: Stent thrombosis (ST) is a rare but serious complication of percutaneous coronary intervention (PCI). The Academic Research Consortium definition of ST excludes events occurring during PCI. METHODS: Angiograms from the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) and HORIZONS-AMI (Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction) trials were reviewed frame-by-frame at an independent core laboratory for the occurrence of IPST...
January 2013: JACC. Cardiovascular Interventions
Daniel S Ong, Ik-Kyung Jang
Stent thrombosis is a rare, but serious, complication of percutaneous coronary intervention and is associated with severe morbidity and mortality. In addition to clinical and pathological studies, intravascular imaging has advanced our understanding of the mechanisms underlying stent thrombosis. In particular, intravascular imaging has been used to study stent underexpansion, malapposition, uncovered struts, and neoatherosclerosis as risk factors for stent thrombosis. Intravascular ultrasonography and optical coherence tomography can be used to guide stent implantation and minimize the risk of stent thrombosis...
June 2015: Nature Reviews. Cardiology
Philippe Généreux, Björn Redfors, Bernhard Witzenbichler, Akiko Maehara, Mayank Yadav, Giora Weisz, Dominic P Francese, Rupa Parvataneni, Sorin J Brener, Roxana Mehran, Ajay J Kirtane, Gregg W Stone
OBJECTIVES: We sought to identify angiographic predictors of 2-year stent thrombosis (ST) in the ADAPT-DES study. BACKGROUND: A strong relationship between platelet reactivity and ST after implantation of drug-eluting stents (DES) was recently confirmed in the prospective, multicenter ADAPT-DES study. METHODS: In a pre-specified analysis of patients enrolled in ADAPT-DES, an independent angiographic core laboratory performed detailed angiographic analyses for all cases of ST...
January 2017: Catheterization and Cardiovascular Interventions
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