Must Read Oncology Preprints

Background: Lung Cancer is the leading cause of cancer deaths in the US, making up almost a quarter of all cancer deaths. Disparities exist upon closer examination: African American (AA) males were found to have a higher incidence of developing lung cancer compared to their Caucasian counterparts. Some plausible reasons for higher incidence rates in AA patients may be due to differences in smoking habits, socioeconomic variables, and metabolism of tobacco carcinogens. Along with these factors, societal differences and lack of resources are postulated to play a significant role...

Purpose: To compare the oncologic outcomes of T2 bladder cancer (BCa) patients after partial cystectomy (PC) or radical cystectomy (RC). Materials and Methods: Relevant data of T2 BCa patients diagnosed between 2004 and 2015 were retrieved from the Surveillance, Epidemiology, and End Results database. After propensity score matching, the oncologic outcomes after PC or RC were compared in patients who underwent lymph node dissection (LND) or not. Additionally, the benefits of different LND strategies were also explored...

Background: The Chondrosarcoma (CS) is the second most frequent common malignant bone tumor, with variety in terms of histopathology, clinical behavior and prognostic outcome. Although the exploration of this topics is extensive, the management for advanced CS is still exceptional challenging. A comprehensive understanding of the profile of the research status and determination of novel directions is of urgent need. Methods: The Web of Science Core Collection (WOSCC) dataset was queried to collect all relevant publications related to CS on March 1, 2022...

No abstract text is available yet for this article.

Background: Preoperative prediction of pancreatic cystic neoplasm (PCN) differentiation has significant value for implementation of personalized diagnosis and treatment plan. This study aims to build radiomics deep learning (DL) models using computed tomography (CT) data for preoperative differential diagnosis of common cystic tumors of pancreas. Methods: Clinical and CT data of 193 patients with PCN was collected for the study. Among these patients, 99 were pathologically diagnosed with pancreatic serous cystadenoma (SCA), 55 with mucinous cystadenoma (MCA) and 39 with intraductal papillary mucinous neoplasm (IPMN)...

Purpose: Carcinoembryonic antigen (CEA) is the most widely used tumor marker in metastatic colorectal cancer (mCRC), but its potential as a predictive marker of progression in mCRC during systemic chemotherapy, particularly in patients receiving monoclonal antibodies as a combination therapy, has remained a question of interest. We here investigated whether CEA changes could predict disease progression and clinical outcomes in mCRC patients who had been co-administered systemic chemotherapy and biologic agents...

Purpose: Continuing employment or returning to work (RTW) as a cancer survivor can be meaningful and financially necessary, yet challenging. However, there is a lack of qualitative research on RTW experiences and financial wellbeing of people with advanced colorectal cancer (CRC-A). This study aimed to fill this gap. Methods: Adults treated for CRC-A were recruited 0.5-2 years post-surgery (or post-diagnosis of CRC-A for palliative chemotherapy participants). Semi-structured telephone interviews, exploring RTW and finances, were subjected to framework analysis...

Background: Cancer related fatigue (CRF) is one of the most debilitating side effects of adjuvant radiation therapy (RT). Several studies have found that physical activity (PA) may be an effective intervention to decrease fatigue and enhance QOL in cancer survivors. Purpose: The primary objective of the PEDLAR study is to test the efficacy of an easily administered 8-week structured moderate-intensity PA intervention, delivered concurrently with RT, in reducing CRF and improving health-related QOL among AA breast cancer patients...

No abstract text is available yet for this article.

Background: Coronavirus disease 2019 (COVID-19) and associated outcomes manifest differently depending on patients’ background and pre-existing conditions. It remains unclear how African Americans with and without cancer have been affected.Aim: To determine epidemiological, clinical comorbidities, and laboratory test results to identify markers associated with mortality in COVID-19 cancer patients. Methods: We reviewed all Covid-19 hospitalized patients records from Dec...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

Background/Aims: The immune system plays a key role in cancer surveillance and modulation of the tumor microenvironment. Humans with inborn errors of immunity (IEI), or primary immunodeficiencies, may be prone to recurrent mucosal bacterial and viral infections and chronic inflammation, associated with intrinsic or secondary epithelium dysfunction, a potential risk factor for early-onset gastrointestinal (GI) cancer. Methods: We systematically reviewed all cases with clinical diagnoses of both an IEI and a GI cancer in three databases (MEDLINE, SCOPUS, EMBASE)...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

Background: Immune checkpoint inhibitors (ICIs) are now a therapeutic standard in advanced non-small cell lung cancer (NSCLC), but strong predictive markers for ICIs efficacy are still lacking. We evaluated machine learning models built on simple clinical and biological data to individually predict response to ICIs. Methods: Patients with metastatic NSCLC who received ICI in second line or later were included. We collected clinical and hematological data and studied the association of this data with disease control rate (DCR), progression free survival (PFS) and overall survival (OS)...

Background: Pancreatic adenocarcinoma (PAAD) is a highly malignant cancer with a poor prognosis. The tumor microenvironment (TME) is closely related to tumorigenesis, progression, and treatment. However, the relationship between TME immune cell genes and prognosis in PAAD is currently unclear. Methods: In this study, we identified three prognostic subtypes based on the TME by using data from The Cancer Genome Atlas (TCGA) database, The International Cancer Genome Consortium (ICGC) database and University of California Santa Cruz (UCSC) database...

Background: Multigene expression assays for molecular subtypes and biomarkers can aid clinical management of early breast cancer. Based on RNA-sequencing we aimed to develop robust single-sample predictor (SSP) models for conventional clinical markers as well as molecular intrinsic subtype and risk of recurrence (ROR) that provide clinically relevant prognostic stratification. Methods: A uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data from fresh tissue was divided into a training set (n=5250) and a reserved test set (n=2412)...

Background: We present a multidisciplinary approach to clinical trial design and analysis in a pilot study (NCT02415621) in which evolution-based mathematical models guide patient-specific dosing for Abiraterone treatment in men with castrate resistant metastatic prostate cancer. Methods: Abiraterone plus prednisone were administered intermittently based on an evolutionary mathematical model. Outcomes are compared to historical controls and a matched contemporaneous cohort who met trial eligibility but received SOC dosing...

Background: The efficacy of RFA in the treatment of HCC with severe fibrosis is still unclear. Objective: of this study is to compare the efficacy of RFA with liver resection in the treatment of HCC within Milan criteria. Methods: The data used in the study were from the SEER database. Patients with HCC within Milan criteria were included in the study. A total of 1432 patients were included in the study; among them, 1038 patients received RFA, and 394 patients received liver resection...