C J Hodiamont, N P Juffermans, S E Berends, D J van Vessem, N Hakkens, R A A Mathôt, M D de Jong, R M van Hest
BACKGROUND: The advocated pharmacokinetic/pharmacodynamic (PK/PD) target for vancomycin, AUC/MIC ≥ 400 mg·h/L, may not be reached with a conventional fixed starting dose of 1000 mg in critically ill patients, but increasing the dose may cause nephrotoxicity. OBJECTIVES: To evaluate the effect of a weight-based loading dose of 25 mg/kg vancomycin on PK/PD target attainment in the first 24 h (AUC0-24) in critically ill patients and to evaluate whether this increases the risk of acute kidney injury (AKI)...
October 11, 2021: Journal of Antimicrobial Chemotherapy
Michael J Rybak, Jennifer Le, Thomas P Lodise, Donald P Levine, John S Bradley, Catherine Liu, Bruce A Mueller, Manjunath P Pai, Annie Wong-Beringer, John C Rotschafer, Keith A Rodvold, Holly D Maples, Benjamin Lomaestro
Recent clinical data on vancomycin pharmacokinetics and pharmacodynamics suggest a reevaluation of current dosing and monitoring recommendations. The previous 2009 vancomycin consensus guidelines recommend trough monitoring as a surrogate marker for the target area under the curve over 24 hours to minimum inhibitory concentration (AUC/MIC). However, recent data suggest that trough monitoring is associated with higher nephrotoxicity. This document is an executive summary of the new vancomycin consensus guidelines for vancomycin dosing and monitoring...
September 12, 2020: Clinical Infectious Diseases
Michael Rybak, Ben Lomaestro, John C Rotschafer, Robert Moellering, William Craig, Marianne Billeter, Joseph R Dalovisio, Donald P Levine
No abstract text is available yet for this article.
January 1, 2009: American Journal of Health-system Pharmacy: AJHP
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