collection
https://read.qxmd.com/read/34961785/neonates-and-covid-19-state-of-the-art-neonatal-sepsis-series
#1
REVIEW
L Ryan, Frans B Plötz, Agnes van den Hoogen, Jos M Latour, Marina Degtyareva, Maya Keuning, Claus Klingenberg, Irwin K M Reiss, Eric Giannoni, Charles Roehr, Christopher Gale, Eleanor J Molloy
The SARS-CoV-2 pandemic has had a significant impact worldwide, particularly in middle- and low-income countries. While this impact has been well-recognized in certain age groups, the effects, both direct and indirect, on the neonatal population remain largely unknown. There are placental changes associated, though the contributions to maternal and fetal illness have not been fully determined. The rate of premature delivery has increased and SARS-CoV-2 infection is proportionately higher in premature neonates, which appears to be related to premature delivery for maternal reasons rather than an increase in spontaneous preterm labor...
January 2022: Pediatric Research
https://read.qxmd.com/read/34955518/multisystem-inflammatory-syndrome-in-a-12-year-old-boy-after-mrna-sars-cov-2-vaccination
#2
JOURNAL ARTICLE
Abobakr A Abdelgalil, Fajr A Saeedi
Multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection is well known. We describe a 12-year-old child developing MIS-C after receiving 2 doses of mRNA COVID-19 vaccines without clinical evidence of COVID-19 infection. A possible association between the SARS-CoV-2 vaccine and MIS-C cannot be excluded.
March 1, 2022: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/34966142/why-does-the-severity-of-covid-19-differ-with-age-understanding-the-mechanisms-underlying-the-age-gradient-in-outcome-following-sars-cov-2-infection
#3
REVIEW
Petra Zimmermann, Nigel Curtis
Although there are many hypotheses for the age-related difference in the severity of COVID-19, differences in innate, adaptive and heterologous immunity, together with differences in endothelial and clotting function, are the most likely mechanisms underlying the marked age gradient. Children have a faster and stronger innate immune response to SARS-CoV-2, especially in the nasal mucosa, which rapidly controls the virus. In contrast, adults can have an overactive, dysregulated and less effective innate response that leads to uncontrolled pro-inflammatory cytokine production and tissue injury...
February 1, 2022: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/34978781/a-case-of-multisystem-inflammatory-syndrome-in-a-12-year-old-male-after-covid-19-mrna-vaccine
#4
JOURNAL ARTICLE
Rumeysa Yalçinkaya, Fatma Nur Öz, Meltem Polat, Berna Uçan, Türkan Aydin Teke, Ayşe Kaman, Suna Özdem, Zeynep Savaş Şen, Rüveyda Gümüşer Cinni, Gönül Tanir
The pathophysiology of multisystem inflammatory syndrome (MIS) in children (MIS-C) is unknown. It occurs several weeks after COVID-19 infection or exposure; however, MIS is rarely reported after COVID-19 vaccination, and cases are mostly in adults. Herein, we present a 12-year-old male who had no prior COVID-19 infection or exposure and developed MIS-C after his first dose of COVID-19 mRNA vaccine.
March 1, 2022: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/34752019/evaluation-of-the-bnt162b2-covid-19-vaccine-in-children-5-to-11-years-of-age
#5
JOURNAL ARTICLE
Emmanuel B Walter, Kawsar R Talaat, Charu Sabharwal, Alejandra Gurtman, Stephen Lockhart, Grant C Paulsen, Elizabeth D Barnett, Flor M Muñoz, Yvonne Maldonado, Barbara A Pahud, Joseph B Domachowske, Eric A F Simões, Uzma N Sarwar, Nicholas Kitchin, Luke Cunliffe, Pablo Rojo, Ernest Kuchar, Mika Rämet, Iona Munjal, John L Perez, Robert W Frenck, Eleni Lagkadinou, Kena A Swanson, Hua Ma, Xia Xu, Kenneth Koury, Susan Mather, Todd J Belanger, David Cooper, Özlem Türeci, Philip R Dormitzer, Uğur Şahin, Kathrin U Jansen, William C Gruber
BACKGROUND: Safe, effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in children younger than 12 years of age. METHODS: A phase 1, dose-finding study and an ongoing phase 2-3 randomized trial are being conducted to investigate the safety, immunogenicity, and efficacy of two doses of the BNT162b2 vaccine administered 21 days apart in children 6 months to 11 years of age. We present results for 5-to-11-year-old children. In the phase 2-3 trial, participants were randomly assigned in a 2:1 ratio to receive two doses of either the BNT162b2 vaccine at the dose level identified during the open-label phase 1 study or placebo...
January 6, 2022: New England Journal of Medicine
https://read.qxmd.com/read/34861180/risk-of-covid-19-hospital-admission-among-children-aged-5-17-years-with-asthma-in-scotland-a-national-incident-cohort-study
#6
JOURNAL ARTICLE
Ting Shi, Jiafeng Pan, Srinivasa Vittal Katikireddi, Colin McCowan, Steven Kerr, Utkarsh Agrawal, Syed Ahmar Shah, Colin R Simpson, Lewis Duthie Ritchie, Chris Robertson, Aziz Sheikh
BACKGROUND: There is an urgent need to inform policy deliberations about whether children with asthma should be vaccinated against SARS-CoV-2 and, if so, which subset of children with asthma should be prioritised. We were asked by the UK's Joint Commission on Vaccination and Immunisation to undertake an urgent analysis to identify which children with asthma were at increased risk of serious COVID-19 outcomes. METHODS: This national incident cohort study was done in all children in Scotland aged 5-17 years who were included in the linked dataset of Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II)...
November 30, 2021: Lancet Respiratory Medicine
https://read.qxmd.com/read/34982107/association-of-birth-during-the-covid-19-pandemic-with-neurodevelopmental-status-at-6-months-in-infants-with-and-without-in-utero-exposure-to-maternal-sars-cov-2-infection
#7
JOURNAL ARTICLE
Lauren C Shuffrey, Morgan R Firestein, Margaret H Kyle, Andrea Fields, Carmela Alcántara, Dima Amso, Judy Austin, Jennifer M Bain, Jennifer Barbosa, Mary Bence, Catherine Bianco, Cristina R Fernández, Sylvie Goldman, Cynthia Gyamfi-Bannerman, Violet Hott, Yunzhe Hu, Maha Hussain, Pam Factor-Litvak, Maristella Lucchini, Arthur Mandel, Rachel Marsh, Danielle McBrian, Mirella Mourad, Rebecca Muhle, Kimberly G Noble, Anna A Penn, Cynthia Rodriguez, Ayesha Sania, Wendy G Silver, Kally C O'Reilly, Melissa Stockwell, Nim Tottenham, Martha G Welch, Noelia Zork, William P Fifer, Catherine Monk, Dani Dumitriu
Importance: Associations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment are speculated, but currently unknown. Objective: To examine the associations between maternal SARS-CoV-2 infection during pregnancy, being born during the COVID-19 pandemic regardless of maternal SARS-CoV-2 status, and neurodevelopment at age 6 months. Design, Setting, and Participants: A cohort of infants exposed to maternal SARS-CoV-2 infection during pregnancy and unexposed controls was enrolled in the COVID-19 Mother Baby Outcomes Initiative at Columbia University Irving Medical Center in New York City...
June 1, 2022: JAMA Pediatrics
https://read.qxmd.com/read/34845526/factors-associated-with-hospital-and-intensive-care-admission-in-paediatric-sars-cov-2-infection-a-prospective-nationwide-observational-cohort-study
#8
JOURNAL ARTICLE
Anita Uka, Michael Buettcher, Sara Bernhard-Stirnemann, Yves Fougère, Dehlia Moussaoui, Lisa Kottanattu, Noémie Wagner, Petra Zimmermann, Nicole Ritz
Coronavirus disease 2019 (COVID-19) is usually less severe in children compared to adults. This study describes detailed clinical characteristics, treatment and outcomes of children with COVID-19 in a non-hospitalised and hospitalised setting and quantifies factors associated with admission to hospital and intensive care unit in children with SARS-CoV-2 infection on a nationwide level. Data were collected through the Swiss Paediatric Surveillance Unit from children < 18 years with confirmed SARS-CoV-2 infection...
March 2022: European Journal of Pediatrics
https://read.qxmd.com/read/34923563/the-covid-19-pandemic-and-its-potential-enduring-impact-on-children
#9
REVIEW
Margaret Irwin, Bojan Lazarevic, Derek Soled, Andrew Adesman
PURPOSE OF REVIEW: The COVID-19 pandemic has ushered in great and rapid change in our society. Although children are somewhat less likely to get infected or have severe symptoms from COVID-19, they are being adversely affected by this global public health emergency in many direct and indirect ways. This review focuses on the major areas in which children and adolescents are suffering, and how pediatricians can anticipate and optimize child healthcare and support as the COVID-19 pandemic and its aftermath continues...
February 1, 2022: Current Opinion in Pediatrics
https://read.qxmd.com/read/34772377/prolonged-rectal-shedding-of-sars-cov-2-in-a-22-day-old-neonate-a-case-report
#10
JOURNAL ARTICLE
Julie Niemann Holm-Jacobsen, Julia Helena Vonasek, Søren Hagstrøm, Mette Line Donneborg, Suzette Sørensen
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the novel coronavirus disease 2019 (COVID-19), which is characterized by a diverse clinical picture. Children are often asymptomatic or experience mild symptoms and have a milder disease course compared to adults. Rectal shedding of SARS-CoV-2 has been observed in both adults and children, suggesting the fecal-oral route as a potential route of transmission. However, only a few studies have investigated this in neonates...
November 12, 2021: BMC Pediatrics
https://read.qxmd.com/read/34794410/mortality-and-clinical-characteristics-of-multisystem-inflammatory-syndrome-in-children-mis-c-associated-with-covid-19-in-critically-ill-patients-an-observational-multicenter-study-misco-study
#11
MULTICENTER STUDY
Lorena Acevedo, Byron Enrique Piñeres-Olave, Laura Fernanda Niño-Serna, Liliana Mazzillo Vega, Ivan Jose Ardila Gomez, Shayl Chacón, Juan Camilo Jaramillo-Bustamante, Hernando Mulett-Hoyos, Otto González-Pardo, Eliana Zemanate, Ledys Izquierdo, Jaime Piracoca Mejìa, Jose Luis Junco González, Beatriz Giraldo Duran, Carolina Bonilla Gonzalez, Helen Preciado, Rafael Orozco Marun, Martha I Alvarez-Olmos, Carolina Giraldo Alzate, Jorge Rojas, Juan Carlos Salazar-Uribe, Juan-Manuel Anaya, Jaime Fernández-Sarmiento
BACKGROUND: The clinical presentation and severity of Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) is widespread and presents a very low mortality rate in high-income countries. This research describes the clinical characteristics of MIS-C in critically ill children in middle-income countries and the factors associated with the rate of mortality and patients with critical outcomes. METHODS: An observational cohort study was conducted in 14 pediatric intensive care units (PICUs) in Colombia between April 01, 2020, and January 31, 2021...
November 18, 2021: BMC Pediatrics
https://read.qxmd.com/read/34847919/management-of-pleural-empyema-in-a-12-year-old-obese-patient-with-covid-19-a-pediatric-case-report
#12
JOURNAL ARTICLE
Reza Abbasi, Farnaz Sadat Javanmardi, Ahmad Mokhtari, Parisa Hosseinpour, Reza Shahriarirad, Kamyar Ebrahimi
BACKGROUND: With the ongoing coronavirus disease (COVID-19) pandemic, along with the development of new mutations of the virus and an increase in the number of cases among pediatrics, physicians should be aware and alerted on the atypical presentations of the disease, especially in less expected individuals. CASE PRESENTATION: Here we present a 12-year-old obese boy (BMI = 37.5 kg/m2 ) who presented with empyema, which was following SARS-CoV-2 infection. The patient had no history of fever...
November 30, 2021: BMC Pediatrics
https://read.qxmd.com/read/34903208/effect-of-covid-19-on-kawasaki-disease-decrease-age-of-onset-and-increase-skin-manifestation
#13
JOURNAL ARTICLE
Hossein Esmaeilzadeh, Negar Mortazavi, Alireza Salehi, Hossein Fatemian, Seyed Mohsen Dehghani, Mohebat Vali, Hossein Molavi Vardanjani
BACKGROUND: Kawasaki Disease (KD) is the most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children. We performed this study to assess the association between KD and COVID-19. We evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period time in 2019 (group two)...
December 13, 2021: BMC Pediatrics
https://read.qxmd.com/read/34911683/child-mortality-in-england-during-the-covid-19-pandemic
#14
JOURNAL ARTICLE
David Odd, Sylvia Stoianova, Tom Williams, Vicky Sleap, Peter Blair, Peter Fleming, Ingrid Wolfe, Karen Luyt
OBJECTIVES: Using the National Child Mortality Database (NCMD), this work aims to investigate and quantify the characteristics of children dying of COVID-19, and to identify any changes in rate of childhood mortality during the pandemic. DESIGN: We compared the characteristics of the children who died in 2020, split by SARS-CoV-2 status. A negative binomial regression model was used to compare mortality rates in lockdown (23 March-28 June), with those children who died in the preceding period (6 January-22 March), as well as a comparable period in 2019...
January 2022: Archives of Disease in Childhood
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