collection
https://read.qxmd.com/read/33626259/audio-interview-the-real-world-effectiveness-of-covid-19-vaccination
#1
EDITORIAL
Eric J Rubin, Lindsey R Baden, Stephen Morrissey
New England Journal of Medicine, Volume 384, Issue 8, February 2021.
February 25, 2021: New England Journal of Medicine
https://read.qxmd.com/read/33631065/interleukin-6-receptor-antagonists-in-critically-ill-patients-with-covid-19
#2
Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Allen C Cheng, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, Francois Lamontagne, Patrick R Lawler, Helen L Leavis, Kelsey M Linstrum, Edward Litton, Elizabeth Lorenzi, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Srinivas Murthy, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettilä, Emma Rademaker, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Steve A Webb, Lennie P G Derde
BACKGROUND: The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS: We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive care unit (ICU), were randomly assigned to receive tocilizumab (8 mg per kilogram of body weight), sarilumab (400 mg), or standard care (control)...
February 25, 2021: New England Journal of Medicine
https://read.qxmd.com/read/33631066/tocilizumab-in-hospitalized-patients-with-severe-covid-19-pneumonia
#3
Ivan O Rosas, Norbert Bräu, Michael Waters, Ronaldo C Go, Bradley D Hunter, Sanjay Bhagani, Daniel Skiest, Mariam S Aziz, Nichola Cooper, Ivor S Douglas, Sinisa Savic, Taryn Youngstein, Lorenzo Del Sorbo, Antonio Cubillo Gracian, David J De La Zerda, Andrew Ustianowski, Min Bao, Sophie Dimonaco, Emily Graham, Balpreet Matharu, Helen Spotswood, Larry Tsai, Atul Malhotra
BACKGROUND: Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better outcomes in patients with severe Covid-19 pneumonia in case reports and retrospective observational cohort studies. Data are needed from randomized, placebo-controlled trials. METHODS: In this phase 3 trial, we randomly assigned patients who were hospitalized with severe Covid-19 pneumonia in a 2:1 ratio receive a single intravenous infusion of tocilizumab (at a dose of 8 mg per kilogram of body weight) or placebo...
February 25, 2021: New England Journal of Medicine
https://read.qxmd.com/read/33657289/choices-in-a-crisis-individual-preferences-among-sars-cov-2-vaccines
#4
Daniel B Kramer, Douglas J Opel, Efthimios Parasidis, Michelle M Mello
No abstract text is available yet for this article.
March 3, 2021: New England Journal of Medicine
https://read.qxmd.com/read/33657291/an-uncertain-public-encouraging-acceptance-of-covid-19-vaccines
#5
Gillian K SteelFisher, Robert J Blendon, Hannah Caporello
No abstract text is available yet for this article.
March 3, 2021: New England Journal of Medicine
https://read.qxmd.com/read/33656519/the-potential-future-of-the-covid-19-pandemic-will-sars-cov-2-become-a-recurrent-seasonal-infection
#6
Christopher J L Murray, Peter Piot
No abstract text is available yet for this article.
March 3, 2021: JAMA
https://read.qxmd.com/read/33656543/filtering-facepiece-respirator-n95-respirator-reprocessing-a-systematic-review
#7
Max A Schumm, Joseph E Hadaya, Nisha Mody, Bethany A Myers, Melinda Maggard-Gibbons
Importance: The COVID-19 pandemic has resulted in a persistent shortage of personal protective equipment; therefore, a need exists for hospitals to reprocess filtering facepiece respirators (FFRs), such as N95 respirators. Objective: To perform a systematic review to evaluate the evidence on effectiveness and feasibility of different processes used for decontaminating N95 respirators. Evidence Review: A search of PubMed and EMBASE (through January 31, 2021) was completed for 5 types of respirator-decontaminating processes including UV irradiation, vaporized hydrogen peroxide, moist-heat incubation, microwave-generated steam, and ethylene oxide...
March 3, 2021: JAMA
https://read.qxmd.com/read/33662101/approaches-for-optimal-use-of-different-covid-19-vaccines-issues-of-viral-variants-and-vaccine-efficacy
#8
John P Moore
No abstract text is available yet for this article.
March 4, 2021: JAMA
https://read.qxmd.com/read/33662092/covid-19-in-2021-continuing-uncertainty
#9
Carlos Del Rio, Preeti Malani
No abstract text is available yet for this article.
March 4, 2021: JAMA
https://read.qxmd.com/read/33662102/effect-of-ivermectin-on-time-to-resolution-of-symptoms-among-adults-with-mild-covid-19-a-randomized-clinical-trial
#10
Eduardo López-Medina, Pío López, Isabel C Hurtado, Diana M Dávalos, Oscar Ramirez, Ernesto Martínez, Jesus A Díazgranados, José M Oñate, Hector Chavarriaga, Sócrates Herrera, Beatriz Parra, Gerardo Libreros, Roberto Jaramillo, Ana C Avendaño, Dilian F Toro, Miyerlandi Torres, Maria C Lesmes, Carlos A Rios, Isabella Caicedo
Importance: Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit. Objective: To determine whether ivermectin is an efficacious treatment for mild COVID-19. Design, Setting, and Participants: Double-blind, randomized trial conducted at a single site in Cali, Colombia. Potential study participants were identified by simple random sampling from the state's health department electronic database of patients with symptomatic, laboratory-confirmed COVID-19 during the study period...
March 4, 2021: JAMA
https://read.qxmd.com/read/33351074/decreased-covid-19-mortality-a-cause-for-optimism
#11
Leon Boudourakis, Amit Uppal
No abstract text is available yet for this article.
December 22, 2020: JAMA Internal Medicine
https://read.qxmd.com/read/33348427/care-bundles-for-improving-outcomes-in-patients-with-covid-19-or-related-conditions-in-intensive-care-a-rapid-scoping-review
#12
Valerie Smith, Declan Devane, Alistair Nichol, David Roche
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain of coronavirus that causes coronavirus disease 2019 (COVID-19) can cause serious illness in some people resulting in admission to intensive care units (ICU) and frequently, ventilatory support for acute respiratory failure. Evaluating ICU care, and what is effective in improving outcomes for these patients is critical. Care bundles, a small set of evidence-based interventions, delivered together consistently, may improve patient outcomes...
December 21, 2020: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/33296566/tocilizumab-for-covid-19-the-ongoing-search-for-effective-therapies
#13
EDITORIAL
Edmund Huang, Stanley C Jordan
New England Journal of Medicine, Volume 383, Issue 24, Page 2387-2388, December 2020.
December 10, 2020: New England Journal of Medicine
https://read.qxmd.com/read/33301245/sars-cov-2-vaccination-an-ounce-actually-much-less-of-prevention
#14
EDITORIAL
Eric J Rubin, Dan L Longo
New England Journal of Medicine, Volume 383, Issue 27, Page 2677-2678, December 2020.
December 10, 2020: New England Journal of Medicine
https://read.qxmd.com/read/33306283/baricitinib-plus-remdesivir-for-hospitalized-adults-with-covid-19
#15
Andre C Kalil, Thomas F Patterson, Aneesh K Mehta, Kay M Tomashek, Cameron R Wolfe, Varduhi Ghazaryan, Vincent C Marconi, Guillermo M Ruiz-Palacios, Lanny Hsieh, Susan Kline, Victor Tapson, Nicole M Iovine, Mamta K Jain, Daniel A Sweeney, Hana M El Sahly, Angela R Branche, Justino Regalado Pineda, David C Lye, Uriel Sandkovsky, Anne F Luetkemeyer, Stuart H Cohen, Robert W Finberg, Patrick E H Jackson, Babafemi Taiwo, Catherine I Paules, Henry Arguinchona, Paul Goepfert, Neera Ahuja, Maria Frank, Myoung-Don Oh, Eu S Kim, Seow Y Tan, Richard A Mularski, Henrik Nielsen, Philip O Ponce, Barbara S Taylor, LuAnn Larson, Nadine G Rouphael, Youssef Saklawi, Valeria D Cantos, Emily R Ko, John J Engemann, Alpesh N Amin, Miki Watanabe, Joanne Billings, Marie-Carmelle Elie, Richard T Davey, Timothy H Burgess, Jennifer Ferreira, Michelle Green, Mat Makowski, Anabela Cardoso, Stephanie de Bono, Tyler Bonnett, Michael Proschan, Gregory A Deye, Walla Dempsey, Seema U Nayak, Lori E Dodd, John H Beigel
BACKGROUND: Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known. METHODS: We conducted a double-blind, randomized, placebo-controlled trial evaluating baricitinib plus remdesivir in hospitalized adults with Covid-19. All the patients received remdesivir (≤10 days) and either baricitinib (≤14 days) or placebo (control)...
December 11, 2020: New England Journal of Medicine
https://read.qxmd.com/read/33326716/emergence-of-a-highly-fit-sars-cov-2-variant
#16
Ralph S Baric
New England Journal of Medicine, Volume 383, Issue 27, Page 2684-2686, December 2020.
December 16, 2020: New England Journal of Medicine
https://read.qxmd.com/read/33332778/regn-cov2-a-neutralizing-antibody-cocktail-in-outpatients-with-covid-19
#17
David M Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Bret J Musser, Yuhwen Soo, Diana Rofail, Joseph Im, Christina Perry, Cynthia Pan, Romana Hosain, Adnan Mahmood, John D Davis, Kenneth C Turner, Andrea T Hooper, Jennifer D Hamilton, Alina Baum, Christos A Kyratsous, Yunji Kim, Amanda Cook, Wendy Kampman, Anita Kohli, Yessica Sachdeva, Ximena Graber, Bari Kowal, Thomas DiCioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos
BACKGROUND: Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. METHODS: In this ongoing, double-blind, phase 1-3 trial involving nonhospitalized patients with Covid-19, we investigated two fully human, neutralizing monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, used in a combined cocktail (REGN-COV2) to reduce the risk of the emergence of treatment-resistant mutant virus...
December 17, 2020: New England Journal of Medicine
https://read.qxmd.com/read/33332779/tocilizumab-in-patients-hospitalized-with-covid-19-pneumonia
#18
Carlos Salama, Jian Han, Linda Yau, William G Reiss, Benjamin Kramer, Jeffrey D Neidhart, Gerard J Criner, Emma Kaplan-Lewis, Rachel Baden, Lavannya Pandit, Miriam L Cameron, Julia Garcia-Diaz, Victoria Chávez, Martha Mekebeb-Reuter, Ferdinando Lima de Menezes, Reena Shah, Maria F González-Lara, Beverly Assman, Jamie Freedman, Shalini V Mohan
BACKGROUND: Coronavirus disease 2019 (Covid-19) pneumonia is often associated with hyperinflammation. Despite the disproportionate incidence of Covid-19 among underserved and racial and ethnic minority populations, the safety and efficacy of the anti-interleukin-6 receptor antibody tocilizumab in patients from these populations who are hospitalized with Covid-19 pneumonia are unclear. METHODS: We randomly assigned (in a 2:1 ratio) patients hospitalized with Covid-19 pneumonia who were not receiving mechanical ventilation to receive standard care plus one or two doses of either tocilizumab (8 mg per kilogram of body weight intravenously) or placebo...
December 17, 2020: New England Journal of Medicine
https://read.qxmd.com/read/32623442/going-back-in-time-for-an-antibody-to-fight-covid-19
#19
COMMENT
Gary R Whittaker, Susan Daniel
No abstract text is available yet for this article.
July 2020: Nature
https://read.qxmd.com/read/32598829/childhood-multisystem-inflammatory-syndrome-a-new-challenge-in-the-pandemic
#20
EDITORIAL
Michael Levin
New England Journal of Medicine, Volume 383, Issue 4, Page 393-395, July 2020.
July 23, 2020: New England Journal of Medicine
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