Gang Wang, Jesse K McKenney
CONTEXT.—: Since the publication of the previous World Health Organization (WHO) Classification of Tumours on the Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs in 2004, significant new knowledge has been generated regarding the pathology and genetics of bladder neoplasia. Publication of the 2016 WHO "Blue Book" has codified that new data into updated recommendations for classification and prognostication. Similarly, the recent release of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, which was implemented in January 2018, has also addressed staging criteria for bladder cancer in several unique settings to clarify their application...
May 2019: Archives of Pathology & Laboratory Medicine
Souzan Sanati
Ductal carcinoma in situ (DCIS) encompasses a highly heterogeneous group of lesions that differ with regard to their clinical presentations, histologic features, biomarker profiles, genetic abnormalities, and potential for progression. DCIS is a nonobligatory precursor for invasive carcinoma. With the advent of screening mammography, the incidence of DCIS has significantly increased. There is an argument that many of these lesions will not progress to invasive carcinoma within the lifetime of a patient. In addition, many studies have found enormous heterogeneity within DCIS...
May 2019: American Journal of Pathology
Martin R Weiser
No abstract text is available yet for this article.
June 2018: Annals of Surgical Oncology
Nathan T Harvey, Benjamin A Wood
CONTEXT.—: Melanocytic lesions are common in routine surgical pathology. Although the majority of these lesions can be confidently diagnosed using well-established morphologic criteria, there is a significant subset of lesions that can be diagnostically difficult. These can be a source of anxiety for patients, clinicians, and pathologists, and the potential consequences of a missed diagnosis of melanoma are serious. OBJECTIVE.—: To provide a practical approach to the diagnosis of melanocytic lesions, including classic problem areas as well as suggestions for common challenges and appropriate incorporation of ancillary molecular techniques...
July 2019: Archives of Pathology & Laboratory Medicine
Guido Rindi, David S Klimstra, Behnoush Abedi-Ardekani, Sylvia L Asa, Frederik T Bosman, Elisabeth Brambilla, Klaus J Busam, Ronald R de Krijger, Manfred Dietel, Adel K El-Naggar, Lynnette Fernandez-Cuesta, Günter Klöppel, W Glenn McCluggage, Holger Moch, Hiroko Ohgaki, Emad A Rakha, Nicholas S Reed, Brian A Rous, Hironobu Sasano, Aldo Scarpa, Jean-Yves Scoazec, William D Travis, Giovanni Tallini, Jacqueline Trouillas, J Han van Krieken, Ian A Cree
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies and contradictions among the various systems currently in use. The classification suggested here is intended to allow pathologists and clinicians to manage their patients with NENs consistently, while acknowledging organ-specific differences in classification criteria, tumor biology, and prognostic factors...
December 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Murali Varma
No abstract text is available yet for this article.
February 2019: American Journal of Surgical Pathology
Hector Mesa, Ajay Rawal, Pankaj Gupta
Objectives: Advances in interventional techniques allow obtaining samples from most body sites through minimally invasive procedures that yield limited samples. We provide practical guidelines for diagnosis of lymphoid lesions in these samples. Methods: Guidelines for selection of biopsy site and triage of the specimen according to results of rapid on-site evaluation (ROSE), and description of the advantages and limitations of currently available ancillary studies are described, based on the experience of the authors, complemented by a comprehensive review of the literature...
October 24, 2018: American Journal of Clinical Pathology
Laura C Collins
The nonobligate precursor lesions columnar cell change/hyperplasia and flat epithelial atypia, atypical ductal hyperplasia and atypical lobular hyperplasia, lobular carcinoma in situ, and low-grade ductal carcinoma in situ share morphologic, immunophenotypic, and molecular features supporting the existence of a low-grade breast neoplasia pathway. The practical implication for pathologists is that the identification of one of these lesions should prompt careful search for others. From a clinical management perspective, however, their designation as "precursor lesions" should not be overemphasized, as the risk of progression among the earliest lesions is exceedingly low...
March 2018: Surgical Pathology Clinics
Zubair W Baloch, Virginia A Livolsi
This review focuses on follicular-patterned lesions of the thyroid gland and their differential diagnosis. Included are a discussion of the features differentiating follicular adenoma from adenomatous or hyperplastic nodule and follicular adenoma from follicular carcinoma and the follicular variant of papillary thyroid carcinoma. The cytologic and histologic characteristics are described, and criteria for diagnosing the major follicular lesions are reviewed.
January 2002: American Journal of Clinical Pathology
Sanpeng Xu, Yuting Dong, Zitian Huo, Lu Yu, Jin Xue, Guoping Wang, Yaqi Duan
AIMS: SOX11 is known as an essential transcription factor for regulating neurogenesis. Recently, SOX11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (MCL). However, SOX11 expression in other tumour types has not yet been extensively studied. METHODS AND RESULTS: Herein, we examined SOX11 expression in 2026 cases of neuroectodermal, germ cell, mesenchymal and epithelial tumours by immunohistochemistry...
February 2019: Histopathology
Stephen M Ansell
DISEASE OVERVIEW: Hodgkin lymphoma (HL) is an uncommon B-cell lymphoid malignancy affecting 8500 new patients annually and representing approximately 10.2% of all lymphomas in the United States. DIAGNOSIS: HL is composed of two distinct disease entities: classical HL and nodular lymphocyte predominant HL. Nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte-rich HL are subgroups of classical HL. RISK STRATIFICATION: An accurate assessment of the stage of disease in patients with HL is critical for the selection of the appropriate therapy...
May 2018: American Journal of Hematology
Arnold Freedman
DISEASE OVERVIEW: Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma (FL) is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement. In general, cytopenias can occur but constitutional symptoms of fever, nightsweats, and weight loss are uncommon. DIAGNOSIS: Diagnosis is based on histology of preferably a biopsy of a lymph node...
February 2018: American Journal of Hematology
Inga-Marie Schaefer, Jason L Hornick
Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms...
November 2018: Advances in Anatomic Pathology
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Antonio Travaglino, Antonio Raffone, Gabriele Saccone, Antonio Mollo, Giuseppe De Placido, Luigi Insabato, Fulvio Zullo
Endometrial hyperplasia (EH) is classified into benign and precancerous according to two different histomorphological systems: the World Health Organisation (WHO) system (based on the subjective evaluation of cytological atypia) and the endometrial intraepithelial neoplasia (EIN) system (based on a combination of several parameters that are assessable subjectively, or objectively through computerised analysis). The American College of Obstetricians and Gynecologists recommends use of the EIN system. Nonetheless, a higher prognostic value for EIN criteria was demonstrated only with the objective assessment, which is not routinely applicable...
April 2019: Histopathology
Mark H Stoler, Thomas C Wright, Alex Ferenczy, James Ranger-Moore, Qijun Fang, Monesh Kapadia, Ruediger Ridder
The diagnosis of squamous intraepithelial lesions in cervical tissue specimens is subject to substantial variability. Adjunctive immunohistochemical (IHC) staining for p16 has been shown to add objective biomarker information to morphologic interpretation of hematoxylin and eosin (H&E)-stained tissues. In the CERvical Tissue AdjunctIve aNalysis (CERTAIN) study, we systematically analyzed the impact of adjunctive p16 IHC on the accuracy (agreement with reference pathology results) of diagnosing cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) in the United States...
August 2018: American Journal of Surgical Pathology
Patricia L Kandalaft, Allen M Gown
CONTEXT: -Identification of the site of origin of carcinoma of unknown primary using immunohistochemistry is a frequent requirement of anatomic pathologists. Diagnostic accuracy is crucial, particularly in the current era of targeted therapies and smaller sample sizes. OBJECTIVES: -To provide practical guidance and suggestions for classifying carcinoma of unknown primary using both proven and new antibodies, as well as targeting panels based on integration of morphologic and clinical features...
June 2016: Archives of Pathology & Laboratory Medicine
P G Casali, N Abecassis, H T Aro, S Bauer, R Biagini, S Bielack, S Bonvalot, I Boukovinas, J V M G Bovee, T Brodowicz, J M Broto, A Buonadonna, E De Álava, A P Dei Tos, X G Del Muro, P Dileo, M Eriksson, A Fedenko, V Ferraresi, A Ferrari, S Ferrari, A M Frezza, S Gasperoni, H Gelderblom, T Gil, G Grignani, A Gronchi, R L Haas, B Hassan, P Hohenberger, R Issels, H Joensuu, R L Jones, I Judson, P Jutte, S Kaal, B Kasper, K Kopeckova, D A Krákorová, A Le Cesne, I Lugowska, O Merimsky, M Montemurro, M A Pantaleo, R Piana, P Picci, S Piperno-Neumann, A L Pousa, P Reichardt, M H Robinson, P Rutkowski, A A Safwat, P Schöffski, S Sleijfer, S Stacchiotti, K Sundby Hall, M Unk, F Van Coevorden, W T A van der Graaf, J Whelan, E Wardelmann, O Zaikova, J Y Blay
No abstract text is available yet for this article.
October 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Manuel Salto-Tellez, Perry Maxwell, Peter Hamilton
No abstract text is available yet for this article.
February 2019: Histopathology
Isabel Amendoeira, Tiago Maia, Manuel Sobrinho-Simões
The 2017 edition of the WHO book on Classification of Tumours of Endocrine Organs includes a new section entitled 'Other encapsulated follicular-patterned thyroid tumours', in which the newly created NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is identified and described in detail. Despite deleting the word 'carcinoma' from its name, NIFTP is not a benign tumor either and is best regarded as a neoplasm with 'very low malignant potential'. The main goal of the introduction of NIFTP category is to prevent overdiagnosis and overtreatment...
April 2018: Endocrine-related Cancer
2018-12-19 16:37:38
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