Critically Appraised Papers

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6 papers 0 to 25 followers Interesting papers highlighted in Critical Appraisal Sessions
Salome Jeyabalan, Suma Mary Thampi, Reka Karuppusami, Kunder Samuel
Background and Aims: Aprepitant, a Neurokinin-1 receptor antagonist, has been evaluated in abdominal and neurosurgeries, but its effect is less clear in breast and thyroid surgeries, which are also known to be high risk for post-operative nausea and vomiting (PONV). This study was done to compare the antiemetic efficacy of ondansetron and aprepitant in women undergoing mastectomy and thyroidectomy. Methods: One hundred and twenty-five ASA I and II, female patients, aged between 18 and 65 years were randomly assigned into Group I (ondansetron group, n = 62) or Group II (aprepitant group, n = 63), by computer-generated random sequencing...
April 2019: Indian Journal of Anaesthesia
Sung Hae Chang, Yun-Kyung Song, Seong-Su Nah
Background: Gumiganghwal-tang (GMGHT) is a traditional herbal medicine consisting of nine different herbs. GMGHT inhibits the mRNA expression and production of inflammatory cytokines tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and TNF- β on lipopolysaccharide- (LPS-) stimulated peritoneal macrophages in a dose-dependent manner. It is empirically used for the treatment of inflammatory disease, but there are few reports of clinical trials that investigate its efficacy and safety...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Amit X Garg, P J Devereaux, Andrew Hill, Manish Sood, Bharat Aggarwal, Luc Dubois, Swapnil Hiremath, Randolph Guzman, Vikram Iyer, Matthew James, Eric McArthur, Louise Moist, George Ouellet, Chirag R Parikh, Virginia Schumann, Sumit Sharan, Heather Thiessen-Philbrook, Sheldon Tobe, Ron Wald, Michael Walsh, Matthew Weir, Neesh Pannu
BACKGROUND: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans. METHODS: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014)...
October 29, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
David E Newby, Philip D Adamson, Colin Berry, Nicholas A Boon, Marc R Dweck, Marcus Flather, John Forbes, Amanda Hunter, Stephanie Lewis, Scott MacLean, Nicholas L Mills, John Norrie, Giles Roditi, Anoop S V Shah, Adam D Timmis, Edwin J R van Beek, Michelle C Williams
BACKGROUND: Although coronary computed tomographic angiography (CTA) improves diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year clinical outcomes is unknown. METHODS: In an open-label, multicenter, parallel-group trial, we randomly assigned 4146 patients with stable chest pain who had been referred to a cardiology clinic for evaluation to standard care plus CTA (2073 patients) or to standard care alone (2073 patients)...
September 6, 2018: New England Journal of Medicine
Yitao He, Zhili Cai, Siling Zeng, Siyan Chen, Bingshan Tang, Yubing Liang, Xin Chang, Yi Guo
OBJECTIVE: To evaluate the effect of fluoxetine on three-year recurrence rate of acute ischemic stroke. PATIENTS AND METHODS: 404 enrolled patients with acute ischemic stroke were randomly divided into control and treatment groups, and underwent conventional secondary preventive therapy for ischemic stroke. In addition, the treatment group was administered fluoxetine (20 mg daily for 90 days). A three-year follow-up was performed, and indicators related to risk factors of stroke were assessed at day 90 of follow-up...
May 2018: Clinical Neurology and Neurosurgery
Ania Zylbersztejn, Ruth Gilbert, Anders Hjern, Linda Wijlaars, Pia Hardelid
BACKGROUND: Child mortality is almost twice as high in England compared with Sweden. We aimed to establish the extent to which adverse birth characteristics and socioeconomic factors explain this difference. METHODS: We developed nationally representative cohorts of singleton livebirths between Jan 1, 2003, and Dec 31, 2012, using the Hospital Episode Statistics in England, and the Swedish Medical Birth Register in Sweden, with longitudinal follow-up from linked hospital admissions and mortality records...
May 19, 2018: Lancet
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